| + |
Ub:E2 | up-regulates activity 
ubiquitination
|
MIB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271133 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MIB1 | up-regulates activity
ubiquitination
|
DLL3 |
0.357 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209672 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16140393 |
Mib physically interacts with Delta and promotes its ubiquitination and internalization [66], which have been shown to up-regulate Notch activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling |
| + |
MIB1 | down-regulates quantity by destabilization 
ubiquitination, polyubiquitination
|
SMN1 |
0.328 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253112 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23615451 |
The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272664 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23615451 |
In this study, we show that the E3 ubiquitin ligase, mind bomb 1 (Mib1), interacts with and ubiquitinates SMN and facilitates its degradation. Knocking down Mib1 levels increases SMN protein levels in cultured cells. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MIB1 | down-regulates
ubiquitination
|
PCM1 |
0.378 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272878 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 24121310 |
We demonstrate that the E3 ubiquitin ligase MIB1 is a new component of centriolar satellites, which interacts with and ubiquitylates AZI1 and PCM1 and suppresses primary cilium formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MIB1 | up-regulates activity
ubiquitination
|
DLL1 |
0.731 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209750 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16140393 |
Mib physically interacts with Delta and promotes its ubiquitination and internalization [66], which have been shown to up-regulate Notch activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling |
| + |
MIB1 | down-regulates
ubiquitination
|
CEP131 |
0.44 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272876 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 24121310 |
We demonstrate that the E3 ubiquitin ligase MIB1 is a new component of centriolar satellites, which interacts with and ubiquitylates AZI1 and PCM1 and suppresses primary cilium formation. Whereas these proteins are degraded prior to the ciliation process, MIB1 appears to maintain its targets in a latent state through inhibitory ubiquitylation that is reversed during ciliogenesis and in response to cell stress.The precise mechanism by which MIB1 inhibits primary cilium formation through ubiquitylation of ciliogenesis-promoting target proteins such as AZI1 and PCM1 remains to be determined. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MIB1 | up-regulates activity
ubiquitination
|
DLL4 |
0.533 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209626 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16140393 |
Mib physically interacts with Delta and promotes its ubiquitination and internalization [66], which have been shown to up-regulate Notch activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling |
| + |
MIB1 | down-regulates quantity by destabilization
polyubiquitination
|
MIB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272603 |
|
|
in vitro |
|
| pmid |
sentence |
| 12351649 |
The RING finger motifs of DIP-1 have E3 ligase activity that can auto-ubiquitinate DIP-1 in vitro. In vivo, DIP-1 is detected as a polyubiquitinated protein, suggesting that the intracellular levels of DIP-1 are regulated by the ubiquitin-proteasome system. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | NOTCH Signaling |
| + |
MIB1 | down-regulates
ubiquitination
|
RYK |
0.333 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176282 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21875946 |
We discovered that ryk both physically and functionally interacts with the e3 ubiquitin ligase mind bomb 1 (mib1).We Found that overexpressed ryk and mib1 colocalized and that the overexpression of mib1 leads to the loss of surface ryk expression. In addition, biochemical studies revealed that mib1 promotes the ubiquitination and degradation of ryk. Endogenous ryk and mib1 were required for the wnt-dependent activation of wnt/ctnnb1 signaling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MIB1 | down-regulates quantity by destabilization
polyubiquitination
|
DAPK1 |
0.448 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272602 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12351649 |
Transient expression of DIP-1 in HeLa cells antagonizes the anti-apoptotic function of DAPK to promote a caspase-dependent apoptosis. These studies also demonstrate that DAPK is an in vitro and in vivo target for ubiquitination by DIP-1, thereby providing a mechanism by which DAPK activities can be regulated through proteasomal degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MIB1 | up-regulates activity
ubiquitination
|
JAG1 |
0.68 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-159480 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18043734 |
Mib1 is essential for the generation of functional notch ligands and regulates the classical notch ligands dll1, dll4, jag1, and jag2 in vertebrates mib1 is an essential e3 ubiquitin ligase for jag1 in the developing cerebellum. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97388 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12530964 |
Mib1 is essential for the generation of functional notch ligands and regulates the classical notch ligands dll1, dll4, jag1, and jag2 in vertebrates mib1 is an essential e3 ubiquitin ligase for jag1 in the developing cerebellum. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| Pathways: | NOTCH Signaling |
3.0
MIB1
- 
- 