4.0
Summary
| Name |  SETD1BView Modifications |
| Full Name | Histone-lysine N-methyltransferase SETD1B |
| Synonyms | Lysine N-methyltransferase 2G, SET domain-containing protein 1B, hSET1B | KIAA1076, KMT2G, SET1B |
| Primary ID | Q9UPS6 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro. |
Viewer
Search Tools
Refine search:
- by mechanism
- by effect
- by organism:
- by tissue:
- by cell-line
Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SETD1B | down-regulates activity 
methylation
|
H3C1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SETD1B | down-regulates activity
methylation
|
H3-4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SETD1B | down-regulates activity
methylation
|
H3-3A | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SETD1B | form complex 
binding
|
MLL/SET subcomplex | 0.897 |
| Publications: | 1 | Organism: | Homo Sapiens | |