| + |
ROCK1 | up-regulates 
phosphorylation
|
MAPK8IP3 |
0.339 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134580 |
Ser314 |
RAREKRDsRNMEVQV |
Homo sapiens |
|
| pmid |
sentence |
| 15767678 |
Identification of rock1 as an upstream activator of the jip-3 to jnk signaling axis in response to uvb damage. phosphorylation of jip-3 by rock1 was crucial for the recruitment of jnk. Inhibition of the activity of rock1 in keratinocytes resulted in decreased activation of the jnk pathway and thus a reduction in apoptosis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134584 |
Ser364 |
TRLDRTGsSPTQGIV |
Homo sapiens |
|
| pmid |
sentence |
| 15767678 |
Identification of rock1 as an upstream activator of the jip-3 to jnk signaling axis in response to uvb damage. phosphorylation of jip-3 by rock1 was crucial for the recruitment of jnk. Inhibition of the activity of rock1 in keratinocytes resulted in decreased activation of the jnk pathway and thus a reduction in apoptosis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134588 |
Ser365 |
RLDRTGSsPTQGIVN |
Homo sapiens |
|
| pmid |
sentence |
| 15767678 |
Identification of rock1 as an upstream activator of the jip-3 to jnk signaling axis in response to uvb damage. phosphorylation of jip-3 by rock1 was crucial for the recruitment of jnk. Inhibition of the activity of rock1 in keratinocytes resulted in decreased activation of the jnk pathway and thus a reduction in apoptosis. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
MAPK10 | up-regulates
phosphorylation
|
MAPK8IP3 |
0.738 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134529 |
Thr265 |
GQSSAAAtPSTTGTK |
Homo sapiens |
|
| pmid |
sentence |
| 15767678 |
Phosphoamino acid analysis confirmed that jnk caused thr phosphorylation of jip3 (fig. _(fig.3c).3c). This phosphorylation on thr was markedly decreased when thr266, thr276, and thr287 were replaced with ala. These data indicate that jnk phosphorylated jip3 on thr266, thr276, and thr287 in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134533 |
Thr275 |
TTGTKSNtPTSSVPS |
Homo sapiens |
|
| pmid |
sentence |
| 15767678 |
Phosphoamino acid analysis confirmed that jnk caused thr phosphorylation of jip3 (fig. _(fig.3c).3c). This phosphorylation on thr was markedly decreased when thr266, thr276, and thr287 were replaced with ala. These data indicate that jnk phosphorylated jip3 on thr266, thr276, and thr287 in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134537 |
Thr286 |
SVPSAAVtPLNESLQ |
Homo sapiens |
|
| pmid |
sentence |
| 15767678 |
Phosphoamino acid analysis confirmed that jnk caused thr phosphorylation of jip3 (fig. _(fig.3c).3c). This phosphorylation on thr was markedly decreased when thr266, thr276, and thr287 were replaced with ala. These data indicate that jnk phosphorylated jip3 on thr266, thr276, and thr287 in vitro. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
MAPK8 | up-regulates
phosphorylation
|
MAPK8IP3 |
0.715 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134541 |
Thr265 |
GQSSAAAtPSTTGTK |
Homo sapiens |
|
| pmid |
sentence |
| 15767678 |
Phosphoamino acid analysis confirmed that jnk caused thr phosphorylation of jip3 (fig. _(fig.3c).3c). This phosphorylation on thr was markedly decreased when thr266, thr276, and thr287 were replaced with ala. These data indicate that jnk phosphorylated jip3 on thr266, thr276, and thr287 in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134545 |
Thr275 |
TTGTKSNtPTSSVPS |
Homo sapiens |
|
| pmid |
sentence |
| 15767678 |
Phosphoamino acid analysis confirmed that jnk caused thr phosphorylation of jip3 (fig. _(fig.3c).3c). This phosphorylation on thr was markedly decreased when thr266, thr276, and thr287 were replaced with ala. These data indicate that jnk phosphorylated jip3 on thr266, thr276, and thr287 in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134549 |
Thr286 |
SVPSAAVtPLNESLQ |
Homo sapiens |
|
| pmid |
sentence |
| 15767678 |
Phosphoamino acid analysis confirmed that jnk caused thr phosphorylation of jip3 (fig. _(fig.3c).3c). This phosphorylation on thr was markedly decreased when thr266, thr276, and thr287 were replaced with ala. These data indicate that jnk phosphorylated jip3 on thr266, thr276, and thr287 in vitro. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
MAPK9 | up-regulates
phosphorylation
|
MAPK8IP3 |
0.652 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134568 |
Thr265 |
GQSSAAAtPSTTGTK |
Homo sapiens |
|
| pmid |
sentence |
| 15767678 |
Phosphoamino acid analysis confirmed that jnk caused thr phosphorylation of jip3 (fig. _(fig.3c).3c). This phosphorylation on thr was markedly decreased when thr266, thr276, and thr287 were replaced with ala. These data indicate that jnk phosphorylated jip3 on thr266, thr276, and thr287 in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134572 |
Thr275 |
TTGTKSNtPTSSVPS |
Homo sapiens |
|
| pmid |
sentence |
| 15767678 |
Phosphoamino acid analysis confirmed that jnk caused thr phosphorylation of jip3 (fig. _(fig.3c).3c). This phosphorylation on thr was markedly decreased when thr266, thr276, and thr287 were replaced with ala. These data indicate that jnk phosphorylated jip3 on thr266, thr276, and thr287 in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134576 |
Thr286 |
SVPSAAVtPLNESLQ |
Homo sapiens |
|
| pmid |
sentence |
| 15767678 |
Phosphoamino acid analysis confirmed that jnk caused thr phosphorylation of jip3 (fig. _(fig.3c).3c). This phosphorylation on thr was markedly decreased when thr266, thr276, and thr287 were replaced with ala. These data indicate that jnk phosphorylated jip3 on thr266, thr276, and thr287 in vitro. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
MAPK8IP3 | up-regulates
binding
|
JNK |
0.74 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269886 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15767678 |
The c-jun nh2-terminal kinase (jnk)-interacting protein (jip) group of scaffold proteins (jip1, jip2, and jip3) can interact with components of the jnk signaling pathway and potently activate jnk. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK8IP3 | up-regulates
binding
|
MAP3K1 |
0.526 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-71471 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10523642 |
Overexpression of full-length jsap1 in cos-7 cells led to a considerable enhancement of jnk3 activation, and modest enhancement of jnk1 and jnk2 activation, by the mekk1-sek1 pathwaythe regions of jsap1 that bound jnk, sek1, and mekk1 were distinct from one another. Jnk and mekk1 also bound jsap1 in vitro, suggesting that these interactions are direct. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK8IP3 | up-regulates
binding
|
MAP2K4 |
0.617 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-71468 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10523642 |
Overexpression of full-length jsap1 in cos-7 cells led to a considerable enhancement of jnk3 activation, and modest enhancement of jnk1 and jnk2 activation, by the mekk1-sek1 pathwaythe regions of jsap1 that bound jnk, sek1, and mekk1 were distinct from one another. Jnk and mekk1 also bound jsap1 in vitro, suggesting that these interactions are direct. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JNK | up-regulates
phosphorylation
|
MAPK8IP3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269984 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15767678 |
Phosphoamino acid analysis confirmed that jnk caused thr phosphorylation of jip3 (fig. _(fig.3c).3c). This phosphorylation on thr was markedly decreased when thr266, thr276, and thr287 were replaced with ala. These data indicate that jnk phosphorylated jip3 on thr266, thr276, and thr287 in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK8IP3 | up-regulates
binding
|
MAP2K7 |
0.691 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-73906 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10629060 |
These data demonstrate that jip3 interacts with proteins that can form a mapk signaling module, including jnk, mkk7, and mlk3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK8IP3 | up-regulates
binding
|
MAPK8 |
0.715 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134558 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15767678 |
The c-jun nh2-terminal kinase (jnk)-interacting protein (jip) group of scaffold proteins (jip1, jip2, and jip3) can interact with components of the jnk signaling pathway and potently activate jnk. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK8IP3 | up-regulates
binding
|
MAPK9 |
0.652 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134561 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15767678 |
The c-jun nh2-terminal kinase (jnk)-interacting protein (jip) group of scaffold proteins (jip1, jip2, and jip3) can interact with components of the jnk signaling pathway and potently activate jnk. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK8IP3 | up-regulates
binding
|
MAP3K11 |
0.536 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-73909 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 10629060 |
These data demonstrate that jip3 interacts with proteins that can form a mapk signaling module, including jnk, mkk7, and mlk3jip3 increases mlk3-stimulated jnk activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
MAPK8IP3 | up-regulates
binding
|
MAPK10 |
0.738 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134555 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15767678 |
The c-jun nh2-terminal kinase (jnk)-interacting protein (jip) group of scaffold proteins (jip1, jip2, and jip3) can interact with components of the jnk signaling pathway and potently activate jnk. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MAPK8IP3
- 
- 