Summary

Name MAPK8IP3
Full Name C-Jun-amino-terminal kinase-interacting protein 3
Synonyms JIP-3, JNK-interacting protein 3, JNK MAP kinase scaffold protein 3, Mitogen-activated protein kinase 8-interacting protein 3 | JIP3, KIAA1066
Primary ID Q9UPT6
Links - -
Type protein
Relations 21
Function The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation MAPK8IP3 0.342
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK8IP3 0.713
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK8IP3 0.649
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK8IP3 0.738
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP3K1 0.521
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK8IP3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK9 0.649
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK10 0.738
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP3K11 0.533
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png binding MAP2K7 0.688
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding JNK 0.74
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK8 0.713
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP2K4 0.615
Publications: 1 Organism: Homo Sapiens