Relation Results

Summary

Name NR4A2
Full Name Nuclear receptor subfamily 4 group A member 2
Synonyms Immediate-early response protein NOT, Orphan nuclear receptor NURR1, Transcriptionally-inducible nuclear receptor | NOT, NURR1, TINUR
Primary ID P43354
Links - -
Type protein
Relations 5
Function Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during developme ...
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Type: Score: Layout: SPV 
0.3980.3070.2970.42MAPK1NR4A2NR3C1SATB2RXRB

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ MAPK1up-regulates img/direct-activation.png phosphorylation NR4A2 0.398
Identifier Residue Sequence Organism Cell Line
SIGNOR-157167 Ser126 SVYYKPSsPPTPTTP Homo sapiens Neuron
pmid sentence
We have shown that erk2 is a kinase to phosphorylate nurr1 on multiple sites. S126 and t132, which are located near af1 core of nurr1, are dominant sites phosphorylated by erk2. reporter gene assays show that nurr1delta124-133/t185a, an erk2 phospho-site mutant form, could not further increase its transcriptional activity on th promoter, suggesting that nurr1 phosphorylation by erk2 may regulate its transcriptional activity on th promoter.
Identifier Residue Sequence Organism Cell Line
SIGNOR-157171 Thr132 SSPPTPTtPGFQVQH Homo sapiens Neuron
pmid sentence
We have shown that erk2 is a kinase to phosphorylate nurr1 on multiple sites. S126 and t132, which are located near af1 core of nurr1, are dominant sites phosphorylated by erk2. reporter gene assays show that nurr1delta124-133/t185a, an erk2 phospho-site mutant form, could not further increase its transcriptional activity on th promoter, suggesting that nurr1 phosphorylation by erk2 may regulate its transcriptional activity on th promoter.
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ NR3C1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NR4A2 0.307
Identifier Residue Sequence Organism Cell Line
SIGNOR-132254 Homo sapiens
pmid sentence
We now show that the other nur factors, nurr1 and nor-1, are also subject to antagonism by gr and that this transrepression appears to involve direct protein-protein interactions between the dbds of gr and nur factors.
Publications: 1 Organism: Homo Sapiens
+ SATB2down-regulates quantity img/direct_inhibition.png transcriptional regulation NR4A2 0.297
Identifier Residue Sequence Organism Cell Line
SIGNOR-268930 Homo sapiens
pmid sentence
Satb2 represses the transcription of Nr4a2. The misexpression of Nr4a2 together with Ctip2 induces expression of SubC-specific genes in wild-type Rsp, and simultaneous knockdown of these two genes in Rsp Satb2-mutant cells prevents their fate transition to SubC identity. Thus, Satb2 serves as a determinant gene in the Rsp regionalization by repressing Nr4a2 and Ctip2 during cortical development
Publications: 1 Organism: Homo Sapiens
+ RXRBup-regulates img/direct-activation.png binding NR4A2 0.42
Identifier Residue Sequence Organism Cell Line
SIGNOR-58309 Homo sapiens Neuron
pmid sentence
The recent discovery that the nuclear transcription factor, nurr1, in heterodimeric tandem with rxr, is unequivocally necessary for the expression of dopaminergic neurons
Publications: 1 Organism: Homo Sapiens
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