| + |
RIMS2 | up-regulates activity 
binding
|
CACNA1D |
0.348 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264356 |
|
|
Homo sapiens |
Cochlear Hair Cell |
| pmid |
sentence |
| 28642685 |
Here, we report an interaction of the C2B domain of RIM2α and RIM3γ with the C-terminus of the pore-forming α-subunit of CaV1.3 channels (CaV1.3α1), which mediate stimulus-secretion coupling at the ribbon synapses of cochlear inner hair cells (IHCs). In conclusion, we propose that RIM2α and RIM3γ directly interact with the C-terminus of the pore-forming subunit of CaV1.3 Ca2+ channels and positively regulate their plasma membrane expression in HEK293 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RIMBP2 | down-regulates activity 
binding
|
RIMS2 |
0.533 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264366 |
|
|
Rattus norvegicus |
PC-12 Cell |
| pmid |
sentence |
| 11988172 |
SH3 domains of RBPs interact with RIMs. The enhancement of depolarization-induced secretion in PC12 cells by fusion proteins that suppress the associations of RBPs with RIMs and α1 suggests that RBPs may repress RIMs, either directly or through associated proteins. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
RIMBP3B | down-regulates activity
binding
|
RIMS2 |
0.358 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264369 |
|
|
Rattus norvegicus |
PC-12 Cell |
| pmid |
sentence |
| 11988172 |
SH3 domains of RBPs interact with RIMs. The enhancement of depolarization-induced secretion in PC12 cells by fusion proteins that suppress the associations of RBPs with RIMs and α1 suggests that RBPs may repress RIMs, either directly or through associated proteins. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
RIMS2 | up-regulates activity
relocalization
|
UNC13B |
0.358 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264383 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31679900 |
N-terminal interactions of RIMs with RAB3 and MUNC13 regulate DCV fusion. Through N-terminal interactions, RIMs position MUNC13 and recruit DCVs via RAB3, which is located on the vesicle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RIMBP3 | down-regulates activity
binding
|
RIMS2 |
0.358 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264365 |
|
|
Rattus norvegicus |
PC-12 Cell |
| pmid |
sentence |
| 11988172 |
SH3 domains of RBPs interact with RIMs. The enhancement of depolarization-induced secretion in PC12 cells by fusion proteins that suppress the associations of RBPs with RIMs and α1 suggests that RBPs may repress RIMs, either directly or through associated proteins. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
RIMBP3C | down-regulates activity
binding
|
RIMS2 |
0.264 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264367 |
|
|
Rattus norvegicus |
PC-12 Cell |
| pmid |
sentence |
| 11988172 |
SH3 domains of RBPs interact with RIMs. The enhancement of depolarization-induced secretion in PC12 cells by fusion proteins that suppress the associations of RBPs with RIMs and α1 suggests that RBPs may repress RIMs, either directly or through associated proteins. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
TSPOAP1 | down-regulates activity
binding
|
RIMS2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264368 |
|
|
Rattus norvegicus |
PC-12 Cell |
| pmid |
sentence |
| 11988172 |
SH3 domains of RBPs interact with RIMs. The enhancement of depolarization-induced secretion in PC12 cells by fusion proteins that suppress the associations of RBPs with RIMs and α1 suggests that RBPs may repress RIMs, either directly or through associated proteins. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
RIMS2 | up-regulates activity
relocalization
|
RAB3A |
0.765 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264377 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31679900 |
N-terminal interactions of RIMs with RAB3 and MUNC13 regulate DCV fusion. Through N-terminal interactions, RIMs position MUNC13 and recruit DCVs via RAB3, which is located on the vesicle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RIMS2 | up-regulates activity
relocalization
|
RAB3C |
0.558 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264378 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31679900 |
N-terminal interactions of RIMs with RAB3 and MUNC13 regulate DCV fusion. Through N-terminal interactions, RIMs position MUNC13 and recruit DCVs via RAB3, which is located on the vesicle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
RIMS2
- 
- 