Relation Results

Summary

Name UNC13B
Full Name Protein unc-13 homolog B
Synonyms Munc13-2, munc13 | UNC13
Primary ID O14795
Links - -
Type protein
Relations 5
Pathways Neurotransmitters release
Function Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter relea ...
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Type: Score: Layout: SPV 
0.70.2670.3590.7980.717UNC13BSynaptic_vesicle_exocytosisRIMS3RIMS2RIMS1SNARE_complex

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Relations
Regulator
Mechanism
target
score ℹ
+ UNC13Bup-regulates img/indirect-activation.png Synaptic_vesicle_exocytosis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264386 Homo sapiens Neuron
pmid sentence
N-terminal interactions of RIMs with RAB3 and MUNC13 regulate DCV fusion. Through N-terminal interactions, RIMs position MUNC13 and recruit DCVs via RAB3, which is located on the vesicle. MUNC13 is proposed to tether synaptic vesicles by bridging between vesicle and plasma membrane via its C2C-domain and C1/C2B-domains
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release
+ RIMS3up-regulates activity img/direct-activation.png relocalization UNC13B 0.267
Identifier Residue Sequence Organism Cell Line
SIGNOR-264384 Homo sapiens
pmid sentence
N-terminal interactions of RIMs with RAB3 and MUNC13 regulate DCV fusion. Through N-terminal interactions, RIMs position MUNC13 and recruit DCVs via RAB3, which is located on the vesicle
Publications: 1 Organism: Homo Sapiens
+ RIMS2up-regulates activity img/direct-activation.png relocalization UNC13B 0.359
Identifier Residue Sequence Organism Cell Line
SIGNOR-264383 Homo sapiens
pmid sentence
N-terminal interactions of RIMs with RAB3 and MUNC13 regulate DCV fusion. Through N-terminal interactions, RIMs position MUNC13 and recruit DCVs via RAB3, which is located on the vesicle
Publications: 1 Organism: Homo Sapiens
+ RIMS1up-regulates activity img/direct-activation.png relocalization UNC13B 0.798
Identifier Residue Sequence Organism Cell Line
SIGNOR-264385 Homo sapiens
pmid sentence
N-terminal interactions of RIMs with RAB3 and MUNC13 regulate DCV fusion. Through N-terminal interactions, RIMs position MUNC13 and recruit DCVs via RAB3, which is located on the vesicle
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release
+ UNC13Bup-regulates activity img/direct-activation.png transcriptional regulation SNARE_complex 0.717
Identifier Residue Sequence Organism Cell Line
SIGNOR-263972 Homo sapiens Neuron
pmid sentence
In neuronal exocytosis, Munc18-1 (aSM-protein) and Munc13-1/2 (similar to CATCHRs) arethe relevant proteins responsible for SNARE-complex formation. Munc18-1 associates with syntaxin-1 in its‘closed’ conformation, i.e. with the regulatory Habc-domain folded against the SNARE (H3-)-domain. Opening-up of syntaxin is catalyzed by the Mun-domainwithin Munc13-1/2 and allows assembly with the partnerSNARE SNAP-25 and possibly VAMP2.
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release
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