Summary

Name UNC13B
Full Name Protein unc-13 homolog B
Synonyms Munc13-2, munc13 | UNC13
Primary ID O14795
Links - -
Type protein
Relations 5
Pathways Neurotransmitters release
Function Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ UNC13Bup-regulates img/indirect-activation.png Synaptic_vesicle_exocytosis 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release
+ RIMS1up-regulates activity img/direct-activation.png relocalization UNC13B 0.791
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release
+ UNC13Bup-regulates activity img/direct-activation.png transcriptional regulation SNARE_complex 0.707
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release
+ RIMS2up-regulates activity img/direct-activation.png relocalization UNC13B 0.365
Publications: 1 Organism: Homo Sapiens
+ RIMS3up-regulates activity img/direct-activation.png relocalization UNC13B 0.269
Publications: 1 Organism: Homo Sapiens