4.0
Summary
| Name |  NUAK2View Modifications |
| Full Name | NUAK family SNF1-like kinase 2 |
| Synonyms | Omphalocele kinase 2, SNF1/AMP kinase-related kinase, SNARK | OMPHK2, SNARK |
| Primary ID | Q9H093 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Pathways | YAP/TAZ regulation |
| Function | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | NUAK2 | down-regulates 
phosphorylation
|
LATS1 | 0.305 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | STK11 | up-regulates 
phosphorylation
|
NUAK2 | 0.274 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NUAK2 | down-regulates activity
phosphorylation
|
LAT | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NUAK2 | up-regulates activity
phosphorylation
|
WDR45 | 0.262 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NUAK2 | down-regulates activity
phosphorylation
|
PPP1R12A | 0.467 |
| Publications: | 1 | Organism: | Homo Sapiens | |