+ |
AKT2 | up-regulates activity
phosphorylation
|
MYO5A |
0.435 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262632 |
Thr1650 |
PTGLRKRtSSIADEG |
Mus musculus |
NIH-3T3 Cell |
pmid |
sentence |
17515613 |
Here we identify an Akt consensus phosphorylation motif in the actin-based motor protein myosin 5a and show that insulin stimulation leads to phosphorylation of myosin 5a at serine 1650. This Akt-mediated phosphorylation event enhances the ability of myosin 5a to interact with the actin cytoskeleton.Taken together, these data indicate that myosin 5a is a newly identified direct substrate of Akt2 and, upon insulin stimulation, phosphorylated myosin 5a facilitates anterograde movement of GLUT4 vesicles along actin to the cell surface. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
MYO5A | up-regulates activity
binding
|
VAMP2 |
0.462 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-269281 |
|
|
Homo sapiens |
|
pmid |
sentence |
21077886 |
Another potential role of myosin Va in LDCV exocytosis lies in facilitating the formation of the SNARE complex, which is needed for fusion of the vesicle with the plasma membrane. Notably, myosin Va binds to at least two SNARE proteins in a Ca2+-dependent manner: at micromolar Ca2+-levels, it binds to VAMP2 located in the membrane of the cargo vesicle via its globular tail domain |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MYO5A | up-regulates activity
binding
|
ACTB |
0.419 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-269280 |
|
|
Homo sapiens |
|
pmid |
sentence |
21077886 |
Myosin Va regulates exocytosis of large dense-core vesicles (LDCVs). interestingly, inhibition of myosin Va potentiates LDCV exocytosis to the same extent as F-actin depolymerization does, suggesting that myosin Va cooperates with the actin cytoskeleton to impede or control LDCV exocytosis |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MYO5A | up-regulates
|
Dense-core_vesicle_exocytosis |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-269279 |
|
|
Homo sapiens |
|
pmid |
sentence |
21077886 |
Myosin Va regulates exocytosis of large dense-core vesicles (LDCVs). interestingly, inhibition of myosin Va potentiates LDCV exocytosis to the same extent as F-actin depolymerization does, suggesting that myosin Va cooperates with the actin cytoskeleton to impede or control LDCV exocytosis |
|
Publications: |
1 |
Organism: |
Homo Sapiens |