| + |
RAB3C | up-regulates 
|
Dense-core_vesicle_exocytosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264376 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31679900 |
Here, we identify the SEC4 ortholog RAB3 and its neuronal effector, RIM1, as essential molecules for neuropeptide and neurotrophin release from dense-core vesicles (DCVs) in mammalian neurons. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB3A | up-regulates
|
Dense-core_vesicle_exocytosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264375 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31679900 |
Here, we identify the SEC4 ortholog RAB3 and its neuronal effector, RIM1, as essential molecules for neuropeptide and neurotrophin release from dense-core vesicles (DCVs) in mammalian neurons. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Neurotransmitters release |
| + |
KIF1A | up-regulates
|
Dense-core_vesicle_exocytosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266893 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 30021165 |
To better understand how KIF1A-driven dense core vesicle (DCV) transport is regulated, we identified the KIF1A interactome and focused on three binding partners, the calcium binding protein calmodulin (CaM) and two synaptic scaffolding proteins: liprin-α and TANC2. We showed that calcium, acting via CaM, enhances KIF1A binding to DCVs and increases vesicle motility. In contrast, liprin-α and TANC2 are not part of the KIF1A-cargo complex but capture DCVs at dendritic spines |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
MYO5A | up-regulates
|
Dense-core_vesicle_exocytosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269279 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21077886 |
Myosin Va regulates exocytosis of large dense-core vesicles (LDCVs). interestingly, inhibition of myosin Va potentiates LDCV exocytosis to the same extent as F-actin depolymerization does, suggesting that myosin Va cooperates with the actin cytoskeleton to impede or control LDCV exocytosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Dense-core_vesicle_exocytosis