| + |
SIRT1 | up-regulates quantity by expression 
transcriptional regulation
|
HYOU1 |
0.383 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255143 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 22564731 |
Our results indicate a novel mechanism by which SIRT1 regulates ER stress by overexpression of ORP150, and suggest that SIRT1 ameliorates palmitate-induced insulin resistance in HepG2 cells via regulation of ER stress. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATF6 | up-regulates quantity by expression
transcriptional regulation
|
HYOU1 |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253752 |
|
|
Homo sapiens |
Gastric Cell Line |
| pmid |
sentence |
| 20861013 |
We recently found that in cultured gastric cells, expression of endoplasmic reticulum (ER) chaperones (such as 150-kDa oxygen-regulated protein (ORP150) and glucose-regulated protein 78 (GRP78)) is induced by NSAIDs and confers protection against NSAID-induced apoptosis, which is important in the development of NSAID-induced gastric lesions. In this study we have found that co-culture of gastric cells with H. pylori suppresses the expression of ER chaperones. This suppression was regulated at the level of transcription and accompanied by a reduction in the level of activating transcription factor 6 (ATF6), one of the transcription factors for ER chaperone genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
HYOU1
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