| + |
MAPK14 | up-regulates activity 
phosphorylation
|
ATF6 |
0.566 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276841 |
Thr166 |
NKTENGLtPKKKIQV |
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 25135476 |
This observation not only confirms the specific role for IFN-γ-induced p38 MAPK-dependent phosphorylation of ATF6 at the T166 site but also indicates a connection between phosphorylation and proteolytic activation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ATF6 | up-regulates quantity by expression
transcriptional regulation
|
DDIT3 |
0.646 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260180 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31226023 |
Apart from ER protein chaperones, ATF6 also induces the expression of CHOP and XBP1, thereby connecting the three UPR branches into an integrated signaling network |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS |
| + |
HSPA5 | down-regulates activity 
binding
|
ATF6 |
0.816 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260179 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31226023 |
Similar to PERK and IRE1, ATF6 is activated by ER stress-induced dissociation from GRP78 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS |
| + |
ATF6 | up-regulates quantity by expression
transcriptional regulation
|
XBP1 (isoform 2) |
0.677 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260184 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31226023 |
Apart from ER protein chaperones, ATF6 also induces the expression of CHOP and XBP1, thereby connecting the three UPR branches into an integrated signaling network |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS |
| + |
ATF6 | up-regulates 
|
Chaperone-mediated protein folding |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260182 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31226023 |
Apart from ER protein chaperones, ATF6 also induces the expression of CHOP and XBP1, thereby connecting the three UPR branches into an integrated signaling network |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PCSK7 | up-regulates
phosphorylation
|
ATF6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-89813 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12076252 |
We discovered that azc, an agent that causes the formation of abnormal proteins, stimulates the stress-activated kinase p38 mapk, which phosphorylates atf6 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATF6 | up-regulates quantity by expression
transcriptional regulation
|
HYOU1 |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253752 |
|
|
Homo sapiens |
Gastric Cell Line |
| pmid |
sentence |
| 20861013 |
We recently found that in cultured gastric cells, expression of endoplasmic reticulum (ER) chaperones (such as 150-kDa oxygen-regulated protein (ORP150) and glucose-regulated protein 78 (GRP78)) is induced by NSAIDs and confers protection against NSAID-induced apoptosis, which is important in the development of NSAID-induced gastric lesions. In this study we have found that co-culture of gastric cells with H. pylori suppresses the expression of ER chaperones. This suppression was regulated at the level of transcription and accompanied by a reduction in the level of activating transcription factor 6 (ATF6), one of the transcription factors for ER chaperone genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATF6 | up-regulates quantity by expression
transcriptional regulation
|
NUCB1 |
0.361 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253753 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17686766 |
we identified nucleobindin 1 (NUCB1) as a novel repressor of the S1P-mediated ATF6 activation. NUCB1 is an ER stress-inducible gene with the promoter region having functional cis-elements for transcriptional activation by ATF6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATF6 | up-regulates activity
binding
|
ATF6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-224202 |
|
|
in vitro |
|
| pmid |
sentence |
| 12805554 |
E4BP4, ATF-6, OASIS, and XBP-1 all formed strong homodimeric associations on the array Transcription factor dimerization can increase the selectivity of protein-DNA interactions and generate a large amount of DNA binding diversity from a relatively small number of proteins |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS |
| + |
S | down-regulates quantity by repression 
transcriptional regulation
|
ATF6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260349 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31226023 |
Activation of the ATF6 pathway by HCoV infection is less studied, and most studies have relied on indirect methods, such as luciferase reporter, due to the lack of a specific antibody. No ATF6 cleavage was detected in cells infected with SARS-CoV, and overexpression of SARSCoV S protein failed to activate ATF6 luciferase reporter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS |
| + |
ATF6 | up-regulates quantity by expression
transcriptional regulation
|
HSPA5 |
0.816 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261565 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 14973138 |
Accordingly, N-terminal fragments of each ATF6 isoform (N-ATF6α and N-ATF6β) were overexpressed in HeLa cells and the effects on GRP78 induction were assessed. When expressed at similar levels, N-ATF6α conferred ∼200-fold greater GRP78 promoter activation than N-ATF6β. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS |
3.0
ATF6
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