Relation Results

Summary

Name NOX1
Full Name NADPH oxidase 1
Synonyms NOX-1, Mitogenic oxidase 1, MOX-1, NADH/NADPH mitogenic oxidase subunit P65-MOX, NOH-1 | MOX1, NOH1
Primary ID Q9Y5S8
Links - -
Type protein
Relations 4
Function NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of ...
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Type: Score: Layout: SPV 
0.20.7410.70.8PRKCBNOX1NOXA1ROSsuperoxide

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PRKCBup-regulates activity img/direct-activation.png phosphorylation NOX1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264729 Thr430 CADHNLKtKKIYFYW in vitro
pmid sentence
Site-directed mutagenesis and isothermal titration calorimetry indicated that protein kinase C-beta1 phosphorylates Nox1 at threonine 429. Moreover, Nox1 threonine 429 phosphorylation facilitated the association of Nox1 with the NoxA1 activation domain and was necessary for NADPH oxidase complex assembly
Publications: 1 Organism: In Vitro
+ NOXA1up-regulates activity img/direct-activation.png binding NOX1 0.741
Identifier Residue Sequence Organism Cell Line
SIGNOR-264710 Homo sapiens HEK-293 Cell
pmid sentence
Tks4 and Tks5 bind NoxA1 through their SH3 domains in a Rac-independent manner|NoxO1 is required for full Nox1 and Nox3 oxidase activity at least partially because of its role in the plasma membrane recruitment of the NoxA1 activator protein|Tks4 and Tks5 support Nox1- and Nox3-dependent ROS generation
Publications: 1 Organism: Homo Sapiens
+ NOX1up-regulates img/direct-activation.png ROS 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264714 Homo sapiens
pmid sentence
Over the last years, six homologs of the cytochrome subunit of the phagocyte NADPH oxidase were found: NOX1, NOX3, NOX4, NOX5, DUOX1, and DUOX2. Together with the phagocyte NADPH oxidase itself (NOX2/gp91phox), the homologs are now referred to as the NOX family of NADPH oxidases. These enzymes share the capacity to transport electrons across the plasma membrane and to generate superoxide and other downstream reactive oxygen species (ROS).
Publications: 1 Organism: Homo Sapiens
+ NOX1up-regulates quantity img/direct-activation.png chemical modification superoxide 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-264721 Homo sapiens
pmid sentence
Over the last years, six homologs of the cytochrome subunit of the phagocyte NADPH oxidase were found: NOX1, NOX3, NOX4, NOX5, DUOX1, and DUOX2. Together with the phagocyte NADPH oxidase itself (NOX2/gp91phox), the homologs are now referred to as the NOX family of NADPH oxidases. These enzymes share the capacity to transport electrons across the plasma membrane and to generate superoxide and other downstream reactive oxygen species (ROS).
Publications: 1 Organism: Homo Sapiens
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