| + |
BZW2 | up-regulates quantity by expression 
transcriptional regulation
|
ERK1/2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261219 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31643092 |
WB showed that BZW2 silence significantly decreased p‐ERK protein level in Colo205 cells, whereas BZW2 overexpression upregulated p‐ERK protein expression in HCT116 cells (Figure 3a,b) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BZW2 | up-regulates quantity by expression
transcriptional regulation
|
ATF4 |
0.424 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261222 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31643092 |
Subsequent research reveals that BZW2 induces ATF4 translation which is a pro‐oncogenic transcription factor |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BZW2 | up-regulates activity 
binding
|
EIF2S1 |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261220 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31643092 |
BZW2, as an evolutionary highly conserved protein, interacts with eIF2 and eIF3 and promotes ternary complex formation in vitro |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BZW2 | up-regulates
|
AKT |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261218 |
|
|
Homo sapiens |
Hepatobiliary Carcinoma Cell |
| pmid |
sentence |
| 30805927 |
Overexpression (or silence) of BZW2 in HCC cells significantly stimulates (or decreases) the activation of the PI3K/AKT/mTOR signaling pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BZW2 | up-regulates activity
binding
|
EIF3A |
0.329 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261221 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31643092 |
BZW2, as an evolutionary highly conserved protein, interacts with eIF2 and eIF3 and promotes ternary complex formation in vitro |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
BZW2
- 
- 