3.0
Summary
| Name |  EPN1View Modifications |
| Full Name | Epsin-1 |
| Synonyms | EH domain-binding mitotic phosphoprotein, EPS-15-interacting protein 1 |
| Primary ID | Q9Y6I3 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CDK1 | down-regulates activity 
phosphorylation
|
EPN1 | 0.328 |
| Publications: | 1 | Organism: | Cricetulus Griseus | |
| + | EPN1 | down-regulates
relocalization
|
EGFR | 0.579 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EPN1 | up-regulates quantity by stabilization 
binding
|
AP-2/clathrin vescicle | 0.647 |
| Publications: | 1 | |||
| + | AP-2 complex | up-regulates activity
binding
|
EPN1 | 0.55 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |