| + |
CNOT3 | down-regulates quantity by repression 
transcriptional regulation
|
TNFRSF11A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261572 |
|
|
Mus musculus |
RAW-264.7 Cell |
| pmid |
sentence |
| 24550297 |
Our results reveal that CNOT3 is a critical regulator of bone mass acting on bone resorption through posttranscriptional down-regulation of RANK mRNA stability, at least in part, even in aging-induced osteoporosis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TNFRSF11A | up-regulates 
|
Osteoclast_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253043 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17572386 |
Osteoclasts are fully differentiated, multi-nucleated cells originating from the hematopoietic monocyte-macrophage linage. RANKL, a member of the tumor necrosis factor (TNF) superfamily, and its receptor RANK are essential regulators of osteoclast maturation and activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNFRSF11A | up-regulates activity
|
NfKb-p65/p50 |
0.264 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253047 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10075662 |
RANK activates NF-κB by interacting with TRAF6 via a novel TRAF6 interaction motif and TRAF6 potentially activates NIK, leading to NF-κB activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRAF6 | up-regulates activity 
binding
|
TNFRSF11A |
0.714 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253045 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10075662 |
TRAF6 interacts with a novel motif located between residues 340 and 358 of RANK. TRAF6-binding region (340-358), but not the TRAF2 or TRAF5-binding region, is necessary and sufficient for RANK-induced NF-kappaB activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNFSF11 | up-regulates activity
binding
|
TNFRSF11A |
0.892 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253042 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12897775 |
RANKL, a member of the tumour necrosis factor superfamily, is most abundantly expressed as a cell-surface protein by bone-marrow stromal cells. It interacts with its receptor RANK (which is encoded by Tnfrsf11a) on macrophages and mature osteoclasts. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TNFRSF11A
- 
- 