| + |
PP2Ca_R1A_Bd | up-regulates activity 
dephosphorylation
|
RAF1 |
0.496 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243538 |
Ser259 |
SQRQRSTsTPNVHMV |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16239230 |
... the PP2A holoenzymes ABC and ABC act downstream of Ras and upstream of MEK1 to promote activation of this MAPK signaling cascade. Furthermore both PP2A holoenzymes were found to associate with Raf1 and catalyze dephosphorylation of inhibitory phospho-Ser-259. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PP2Ca_R1A_Bd | down-regulates activity 
dephosphorylation
|
DCK |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275802 |
Ser74 |
EFEELTMsQKNGGNV |
|
|
| pmid |
sentence |
| 24462681 |
Protein phosphatase 2A regulates deoxycytidine kinase activity via Ser-74 dephosphorylation|Deoxycytidine kinase (dCK) is a critical enzyme for activation of anticancer nucleoside analogs. Its activity is controlled via Ser-74 phosphorylation. Here, we investigated which Ser/Thr phosphatase dephosphorylates Ser-74. In cells, the PP1/PP2A inhibitor okadaic acid increased both dCK activity and Ser-74 phosphorylation |
|
| Publications: |
1 |
| + |
PPP2CA | form complex 
binding
|
PP2Ca_R1A_Bd |
0.903 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243433 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23454242 |
[PP2A] ... is multifarious as it is composed of catalytic, scaffold and regulatory subunits. The catalytic and scaffold subunits have two isoforms and the regulatory subunit has four different families containing different isoforms. The regulatory subunit is the most diverse with temporal and spatial specificity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2R5D | form complex
binding
|
PP2Ca_R1A_Bd |
0.851 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243439 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23454242 |
[PP2A] ... is multifarious as it is composed of catalytic, scaffold and regulatory subunits. The catalytic and scaffold subunits have two isoforms and the regulatory subunit has four different families containing different isoforms. The regulatory subunit is the most diverse with temporal and spatial specificity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2R1A | form complex
binding
|
PP2Ca_R1A_Bd |
0.906 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243436 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23454242 |
[PP2A] ... is multifarious as it is composed of catalytic, scaffold and regulatory subunits. The catalytic and scaffold subunits have two isoforms and the regulatory subunit has four different families containing different isoforms. The regulatory subunit is the most diverse with temporal and spatial specificity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PP2Ca_R1A_Bd