+ |
PRKACA | up-regulates
phosphorylation
|
PPP2R5D |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-153218 |
Ser573 |
KVLLRRKsELPQDVY |
Homo sapiens |
|
pmid |
sentence |
17301223 |
Protein kinase a activates protein phosphatase 2a by phosphorylation of the b56delta subunit. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ATM | up-regulates activity
phosphorylation
|
PPP2R5D |
0.301 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-276319 |
|
|
Homo sapiens |
U2-OS Cell |
pmid |
sentence |
21460856 |
In the present study, we demonstrate that ataxia-telangiectasia mutated (ATM) directly phosphorylates and specifically regulates B56γ3, B56γ2 and B56δ, after DNA damage. We further show that phosphorylation of B56γ3 at Ser510 leads to an increase in B56γ3-PP2A complexes, and direction of PP2A phosphatase activity toward the substrate p53, activating its tumor-suppressive functions. we show that Ser510 phosphorylation significantly enhances the ability of B56γ3 to inhibit cell proliferation and anchorage-independent growth. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PPP2R5D | form complex
binding
|
PP2Ca_R1A_Bd |
0.851 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-243439 |
|
|
Homo sapiens |
|
pmid |
sentence |
23454242 |
[PP2A] ... is multifarious as it is composed of catalytic, scaffold and regulatory subunits. The catalytic and scaffold subunits have two isoforms and the regulatory subunit has four different families containing different isoforms. The regulatory subunit is the most diverse with temporal and spatial specificity. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PPP2R5D | up-regulates activity
binding
|
RAF1 |
0.425 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-243420 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
16239230 |
... the PP2A holoenzymes ABC and ABC act downstream of Ras and upstream of MEK1 to promote activation of this MAPK signaling cascade. Furthermore both PP2A holoenzymes were found to associate with Raf1 and catalyze dephosphorylation of inhibitory phospho-Ser-259. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |