| + |
SETDB1 | form complex 
binding
|
SETDB1/NLK/CHD7 |
0.527 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253522 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21952300 |
The non-canonical WNT ligand WNT5A activates the histone methyltransferase SET domain bifurcated 1 (SETDB1)42. SETDB1 forms a complex with chromodomain helicase DNA-binding 7 (CHD7) and NEMO-like kinase (NLK) to inhibit the ability of PPARγ to transcriptionally activate its downstream metabolic target genes in the MSC cell line ST2 and in 3T3‑L1 cells42,43. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CHD7 | form complex
binding
|
SETDB1/NLK/CHD7 |
0.479 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253526 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21952300 |
The non-canonical WNT ligand WNT5A activates the histone methyltransferase SET domain bifurcated 1 (SETDB1)42. SETDB1 forms a complex with chromodomain helicase DNA-binding 7 (CHD7) and NEMO-like kinase (NLK) to inhibit the ability of PPARγ to transcriptionally activate its downstream metabolic target genes in the MSC cell line ST2 and in 3T3‑L1 cells42,43. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FZD2 | up-regulates activity 
|
SETDB1/NLK/CHD7 |
0.399 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253521 |
|
|
|
|
| pmid |
sentence |
| 21952300 |
The non-canonical WNT ligand WNT5A activates the histone methyltransferase SET domain bifurcated 1 (SETDB1)42. SETDB1 forms a complex with chromodomain helicase DNA-binding 7 (CHD7) and NEMO-like kinase (NLK) to inhibit the ability of PPARγ to transcriptionally activate its downstream metabolic target genes in the MSC cell line ST2 and in 3T3‑L1 cells42,43. |
|
| Publications: |
1 |
| + |
SETDB1/NLK/CHD7 | down-regulates activity 
|
PPARG |
0.432 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253524 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21952300 |
The non-canonical WNT ligand WNT5A activates the histone methyltransferase SET domain bifurcated 1 (SETDB1). SETDB1 forms a complex with chromodomain helicase DNA-binding 7 (CHD7) and NEMO-like kinase (NLK) to inhibit the ability of PPARγ to transcriptionally activate its downstream metabolic target genes in the MSC cell line ST2 and in 3T3-L1 cells |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NLK | form complex
binding
|
SETDB1/NLK/CHD7 |
0.423 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253525 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21952300 |
The non-canonical WNT ligand WNT5A activates the histone methyltransferase SET domain bifurcated 1 (SETDB1)42. SETDB1 forms a complex with chromodomain helicase DNA-binding 7 (CHD7) and NEMO-like kinase (NLK) to inhibit the ability of PPARγ to transcriptionally activate its downstream metabolic target genes in the MSC cell line ST2 and in 3T3‑L1 cells42,43. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
SETDB1/NLK/CHD7