| + |
ZNRF3 | down-regulates quantity by destabilization 
ubiquitination
|
FZD2 |
0.297 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197414 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22575959 |
Here we show that the cell-surface transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) and its homologue ring finger 43 (RNF43) are negative feedback regulators of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZNRF3 | down-regulates
ubiquitination, relocalization
|
FZD2 |
0.297 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197417 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22575959 |
Znrf3 is associated with the wnt receptor complex, and inhibits wntby promoting the turnover of frizzled and lrp6. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199650 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Znrf3 is associated with the wnt receptor complex, and inhibits wntby promoting the turnover of frizzled and lrp6. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FZD2 | up-regulates activity 
binding
|
DVL3 |
0.626 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258962 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Upon ligand binding, DVL proteins are recruited to Frizzled receptors at the plasma membrane and co-recruit cytoplasmic transducers, such as Axin, CK1 and GSK3 binding protein (GBP), presumably along with their partners, to promote ?-catenin-dependent signalling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD2 | down-regulates 
|
CEBPA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80601 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 10937998 |
Wnt signaling maintains preadipocytes in an undifferentiated state through inhibition of the adipogenic transcription factors ccaat/enhancer binding protein alpha (c/ebpalpha) and peroxisome proliferator- activated receptor gamma (ppargamma) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD2 | up-regulates activity
binding
|
DVL1 |
0.654 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258956 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Upon ligand binding, DVL proteins are recruited to Frizzled receptors at the plasma membrane and co-recruit cytoplasmic transducers, such as Axin, CK1 and GSK3 binding protein (GBP), presumably along with their partners, to promote ?-catenin-dependent signalling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD2 | up-regulates activity
binding
|
LRP5 |
0.675 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258968 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25902418 |
Here we report that Wnt receptor Frizzled (Frz) and theco-receptors LRP5 and LRP6 (LRP5/6) directly interact with each other and this interaction is regulated by the LRP6 ectodomain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT5A | down-regulates
binding
|
FZD2 |
0.757 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-189120 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19910923 |
Fz2 was also required for the wnt3a-dependent accumulation of beta-catenin, and wnt5a competed with wnt3a for binding to fz2 in vitro and in intact cells, thereby inhibiting the beta-catenin pathway.Wnt5a Internalized fz2 probably with ror1 or ror2 through the clathrin-mediated route, whereas wnt5a competed with wnt3a for binding to fz2 to inhibit the beta-catenin pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-23441 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2808370 |
Fz2 was also required for the wnt3a-dependent accumulation of beta-catenin, and wnt5a competed with wnt3a for binding to fz2 in vitro and in intact cells, thereby inhibiting the beta-catenin pathway. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FZD2 | up-regulates activity
binding
|
LRP6 |
0.654 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258965 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18077588 |
Here we show that both Fz and Dvl functions are critical for Wnt-induced Lrp6 phosphorylation through Fz-Lrp6 interaction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD2 | up-regulates activity
|
SETDB1/NLK/CHD7 |
0.399 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253521 |
|
|
|
|
| pmid |
sentence |
| 21952300 |
The non-canonical WNT ligand WNT5A activates the histone methyltransferase SET domain bifurcated 1 (SETDB1)42. SETDB1 forms a complex with chromodomain helicase DNA-binding 7 (CHD7) and NEMO-like kinase (NLK) to inhibit the ability of PPARγ to transcriptionally activate its downstream metabolic target genes in the MSC cell line ST2 and in 3T3‑L1 cells42,43. |
|
| Publications: |
1 |
| + |
FZD2 | down-regulates
|
PPARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80604 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 10937998 |
Wnt signaling maintains preadipocytes in an undifferentiated state through inhibition of the adipogenic transcription factors ccaat/enhancer binding protein alpha (c/ebpalpha) and peroxisome proliferator- activated receptor gamma (ppargamma) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNF43 | up-regulates
relocalization
|
FZD2 |
0.313 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199585 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Frizzled receptors are regu__lated by cycles of ubiquitylation and deubiquitylation61 (see above), and znrf3 and rnf43 act as frizzled ubiquitin ligases, removing frizzled and possibly lrp6 from the plasma membrane |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT10B | up-regulates
binding
|
FZD2 |
0.626 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-89137 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12055200 |
Inhibition of adipogenesis by wnt10b is likely mediated by wnt receptors, frizzled 1, 2, and/or 5, and co-receptors low density lipoprotein receptor-related proteins 5 and 7 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD2 | up-regulates activity
binding
|
DVL2 |
0.636 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258959 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Upon ligand binding, DVL proteins are recruited to Frizzled receptors at the plasma membrane and co-recruit cytoplasmic transducers, such as Axin, CK1 and GSK3 binding protein (GBP), presumably along with their partners, to promote ?-catenin-dependent signalling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT3A | up-regulates
binding
|
FZD2 |
0.744 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-189117 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19910923 |
It was also shown that wnt5a inhibits the beta-catenin pathway by competing with wnt3a for binding to fz2, and that the impairment of clathrin-mediated internalization does not affect this wnt5a inhibitory action. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT5A | up-regulates activity
binding
|
FZD2 |
0.757 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253520 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19008118 |
Perhaps through Wnt5a acting via FZD2, might also inhibit adipocyte differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FZD2
- 
- 