| + |
CLOCK/BMAL2 | up-regulates quantity by expression 
transcriptional regulation
|
SERPINE1 |
0.496 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253713 |
|
|
Homo sapiens |
Colorectal Cancer Cell |
| pmid |
sentence |
| 22198637 |
Both CLOCK:ARNTL and CLOCK:ARNTL2 heterodimers powerfully activate the promoter of the PAI-1 gene, officially called SERPINE1 and located on the seventh chromosome (7q21.3-q22), underlying the circadian variation in circulating PAI-1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
| + |
CLOCK | form complex 
binding
|
CLOCK/BMAL2 |
0.665 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253711 |
|
|
|
|
| pmid |
sentence |
| 19605937 |
Like BMAL1, its paralog BMAL2 dimerizes with CLOCK to activate the E-box-dependent transcription |
|
| Publications: |
1 |
| Pathways: | Circadian clock |
| + |
ARNTL2 | form complex
binding
|
CLOCK/BMAL2 |
0.665 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253710 |
|
|
|
|
| pmid |
sentence |
| 19605937 |
Like BMAL1, its paralog BMAL2 dimerizes with CLOCK to activate the E-box-dependent transcription |
|
| Publications: |
1 |
3.0
CLOCK/BMAL2
CPX-3230