| + |
RBBP8 | up-regulates activity 
relocalization
|
BRCC ubiquitin ligase complex |
0.606 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263202 |
|
|
|
|
| pmid |
sentence |
| 24832651 |
DNA damage activates ATM and CHK2 kinases, which mediate phosphorylation of CtIP and BRCA1. Phosphorylated CtIP associates with BRCA1 and with the MRN complex leading to the recruitment of the BRCC complex at the site of DNA damage where HR is initiated. |
|
| Publications: |
1 |
| + |
BRCC ubiquitin ligase complex | up-regulates 
|
DNA_repair |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263204 |
|
|
|
|
| pmid |
sentence |
| 24832651 |
The exact function of the BRCC complex in HR is not entirely elucidated, but its E3 ligase activity may promote the mobilization and stabilization of the complex at broken chromatin sites were the complex can stabilize the formation of RAD51 filaments thus facilitating the repair process |
|
| Publications: |
1 |
| + |
BRCC3 | form complex 
binding
|
BRCC ubiquitin ligase complex |
0.545 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263205 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14636569 |
These findings identify BRCC as a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage.|Reconstitution of a recombinant four-subunit complex containing BRCA1/BARD1/BRCC45/BRCC36 revealed an enhanced E3 ligase activity compared to that of BRCA1/BARD1 heterodimer |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BABAM2 | form complex
binding
|
BRCC ubiquitin ligase complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263209 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14636569 |
These findings identify BRCC as a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage.|Reconstitution of a recombinant four-subunit complex containing BRCA1/BARD1/BRCC45/BRCC36 revealed an enhanced E3 ligase activity compared to that of BRCA1/BARD1 heterodimer |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAD51 | form complex
binding
|
BRCC ubiquitin ligase complex |
0.737 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263206 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14636569 |
These findings identify BRCC as a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage.|Reconstitution of a recombinant four-subunit complex containing BRCA1/BARD1/BRCC45/BRCC36 revealed an enhanced E3 ligase activity compared to that of BRCA1/BARD1 heterodimer |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BRCA1-BARD1 complex | form complex
binding
|
BRCC ubiquitin ligase complex |
0.837 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263208 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14636569 |
These findings identify BRCC as a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage.|Reconstitution of a recombinant four-subunit complex containing BRCA1/BARD1/BRCC45/BRCC36 revealed an enhanced E3 ligase activity compared to that of BRCA1/BARD1 heterodimer |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BRCC ubiquitin ligase complex |
ubiquitination
|
TP53 |
0.598 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263210 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14636569 |
However, since the same domain of p53 is also the target of ubiquitination by MDM2 protein, further in vivo experiments are required to demonstrate the biological relevance of p53 ubiquitination by BRCC.|The Extreme C Terminus of p53 Is Ubiquitinated by BRCC |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BRCA2 | form complex
binding
|
BRCC ubiquitin ligase complex |
0.754 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263207 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14636569 |
These findings identify BRCC as a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage.|Reconstitution of a recombinant four-subunit complex containing BRCA1/BARD1/BRCC45/BRCC36 revealed an enhanced E3 ligase activity compared to that of BRCA1/BARD1 heterodimer |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
BRCC ubiquitin ligase complex
CPX-955