| + |
H2BC11 | form complex 
binding
|
Nucleosome_H3.3 variant |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263875 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15776021 |
Variant histone H3.3 is incorporated into nucleosomes by a mechanism that does not require DNA replication and has also been implicated as a potential mediator of epigenetic memory of active transcriptional states. In this study, we have used chromatin immunoprecipitation analysis to show that H3.3 is found mainly at the promoters of transcriptionally active genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
H4C1 | form complex
binding
|
Nucleosome_H3.3 variant |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263877 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15776021 |
Variant histone H3.3 is incorporated into nucleosomes by a mechanism that does not require DNA replication and has also been implicated as a potential mediator of epigenetic memory of active transcriptional states. In this study, we have used chromatin immunoprecipitation analysis to show that H3.3 is found mainly at the promoters of transcriptionally active genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
H3-3A | form complex
binding
|
Nucleosome_H3.3 variant |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263876 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15776021 |
Variant histone H3.3 is incorporated into nucleosomes by a mechanism that does not require DNA replication and has also been implicated as a potential mediator of epigenetic memory of active transcriptional states. In this study, we have used chromatin immunoprecipitation analysis to show that H3.3 is found mainly at the promoters of transcriptionally active genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Nucleosome_H3.3 variant | up-regulates 
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263878 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15776021 |
Variant histone H3.3 is incorporated into nucleosomes by a mechanism that does not require DNA replication and has also been implicated as a potential mediator of epigenetic memory of active transcriptional states. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Nucleosome_H3.3 variant | down-regulates 
|
Transcritpional_activation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273457 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15623580 |
All these studies indicate the possibility that disruption of nucleosomes can take place independently of replication and can be coupled with transcription.The exchange of core histones on mitotic chromatin at anaphase and telophase observed by FRAP may reflect the replacement of a subset of nucleosomes in genome regions that are transcriptionally reactivated in the earliest parts of the new cell cycle. This interpretation is consistent with evidence of chromatin remodeling and chromatin association with RNA pol II at the anaphase–telophase transition (Fig. 9; Prasanth et al., 2003). In situ incorporation of Br-U for 5 min at the same stage showed little labeling outside of NORs (Fig. 9), suggesting that the majority of transcription is yet to commence at this point. The replacement of core histones conceivably precedes transcription to allow the clearance of promoter regions for factors to engage. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
H2AC4 | form complex
binding
|
Nucleosome_H3.3 variant |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263874 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15776021 |
Variant histone H3.3 is incorporated into nucleosomes by a mechanism that does not require DNA replication and has also been implicated as a potential mediator of epigenetic memory of active transcriptional states. In this study, we have used chromatin immunoprecipitation analysis to show that H3.3 is found mainly at the promoters of transcriptionally active genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Nucleosome_H3.3 variant