| + |
AGO2 | form complex 
binding
|
DICER1/hAgo2/PRKRA |
0.807 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143102 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23661684 |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DICER1 | form complex
binding
|
DICER1/hAgo2/PRKRA |
0.892 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143105 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23661684 |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DICER1/hAgo2/PRKRA | up-regulates 
|
NcRNA_processing |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255322 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23661684 |
To test small RNA processing by such PACT-containing complexes, we tested the substrates described above for cleavage rates (pre-let-7a, pre-miR-34c and dsRNA W1) and product length specificity (pre-miR-200a and pre-miR-34c). The results of these experiments showed that Dicer–Ago2–TRBP and Dicer–Ago2–PACT produce the same miRNA products from pre-miR-200a and pre-miR-34c substrates as observed for Dicer–TRBP and Dicer–PACT, respectively (Figure 3A). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKRA | form complex
binding
|
DICER1/hAgo2/PRKRA |
0.759 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255318 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23661684 |
Immunoprecipitation and reconstitution experiments in various systems have shown that Dicer associates with proteins in the Argonaute (Ago) family of endonucleases and with specific double-stranded RNA-binding proteins (dsRBPs) (3–7). | In humans, these dsRBPs are protein activator of PKR (PACT) (5) and trans-activation response RNA-binding protein (TRBP) (3,4). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
DICER1/hAgo2/PRKRA
CPX-1072