| + |
Integrator complex | up-regulates 
|
NcRNA_processing |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261475 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26220997 |
In vivo knockdown and rescue experiments confirmed that the 3′ end processing of HVS pre-miRNAs also depends on Integrator activity. Interaction between Integrator and HVS primary miRNA (pri-miRNA) substrates that contain only the miRNA 3′ box was confirmed by coimmunoprecipitation and an in situ proximity ligation assay (PLA) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RISC(DICER1/AGO2/TARBP2) | up-regulates
|
NcRNA_processing |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255323 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23661684 |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DICER1/hAgo2/PRKRA | up-regulates
|
NcRNA_processing |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255322 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23661684 |
To test small RNA processing by such PACT-containing complexes, we tested the substrates described above for cleavage rates (pre-let-7a, pre-miR-34c and dsRNA W1) and product length specificity (pre-miR-200a and pre-miR-34c). The results of these experiments showed that Dicer–Ago2–TRBP and Dicer–Ago2–PACT produce the same miRNA products from pre-miR-200a and pre-miR-34c substrates as observed for Dicer–TRBP and Dicer–PACT, respectively (Figure 3A). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Microprocessor complex | up-regulates
|
NcRNA_processing |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264850 |
|
|
|
|
| pmid |
sentence |
| 24581491 |
Microprocessor minimally comprises the ribonuclease DROSHA and its double-stranded RNA-binding partner DGCR8 (Denli et al., 2004; Gregory et al., 2004). Microprocessor recognizes pri-miRNA through the stem-loop (Zeng et al., 2005) and the stem-loop-ssRNA junction (Han et al., 2006), and cleaves both the 5′ and 3′ flanking segments to generate pre-miRNA. |
|
| Publications: |
1 |
3.0
NcRNA_processing