| + |
EXT1 | up-regulates activity 
|
BMP4 |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264018 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24860992 |
Decreased Ext1 was shown to reduce the level of Wnt8 and BMP4 signaling and disrupt ventral-specific gene expression. Ext1 function is required for maintenance of normal levels of BMP and wnt, as well as their target genes. In addition, expression of xbra and the establishment of ventral mesoderm depend upon normal levels of Ext1. These findings suggest that ext1-dependent synthesis of HSPG is critical for wnt and BMP signaling, mesodermal identity, and ventral pattern. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EXT1 | up-regulates activity
|
WNT8B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264020 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24860992 |
Decreased Ext1 was shown to reduce the level of Wnt8 and BMP4 signaling and disrupt ventral-specific gene expression. Ext1 function is required for maintenance of normal levels of BMP and wnt, as well as their target genes. In addition, expression of xbra and the establishment of ventral mesoderm depend upon normal levels of Ext1. These findings suggest that ext1-dependent synthesis of HSPG is critical for wnt and BMP signaling, mesodermal identity, and ventral pattern. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EXT1 | form complex 
binding
|
EXT1/EXT2 |
0.563 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109938 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11518722 |
Biochemical analysis shows that ext1 and ext2 are type ii transmembrane glycoproteins and form a golgi-localized hetero-oligomeric complex that catalyzes the polymerization of hs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EXT1 | up-regulates activity
|
WNT8A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264019 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24860992 |
Decreased Ext1 was shown to reduce the level of Wnt8 and BMP4 signaling and disrupt ventral-specific gene expression. Ext1 function is required for maintenance of normal levels of BMP and wnt, as well as their target genes. In addition, expression of xbra and the establishment of ventral mesoderm depend upon normal levels of Ext1. These findings suggest that ext1-dependent synthesis of HSPG is critical for wnt and BMP signaling, mesodermal identity, and ventral pattern. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
EXT1
- 
- 