| + |
CyclinE1/CDK3 |
phosphorylation
|
CABLES1 |
0.488 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273183 |
Ser273 |
PGQGGSTsAFEQLQR |
in vitro |
|
| pmid |
sentence |
| 11733001 |
Here, we report that Ser274 of p70ik3-1 is phosphorylated by cdk2 or cdk3 bound to cyclin A and to cyclin E in vitro. We also found that in COS7 cells in which cyclin E and cdk3 were ectopically overexpressed, the phosphorylation level of Ser274 in coexpressed p70ik3-1 is upregulated. We therefore conclude that p70ik3-1 is a substrate for cdk3-mediated phosphorylation. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CyclinE1/CDK3 | up-regulates activity 
phosphorylation
|
LIN9 |
0.387 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273184 |
Thr96 |
KFTATMStPDKKASQ |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 24475316 |
In this report, we demonstrate that cyclin e1/cdk3 phosphorylates lin-9 on thr-96. Mutating thr-96 to alanine inhibits activation of cyclins a2 and b1 promoters, whereas a phosphomimetic asp mutant strongly activates their promoters and triggers accelerated entry into g2/m phase in 293t cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK3 | form complex 
binding
|
CyclinE1/CDK3 |
0.754 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273185 |
|
|
|
|
| pmid |
sentence |
| 37104883 |
Among them, CDK3 is critically important because it triggers the transitions of G0 to G1 and G1 to S phase through binding to cyclin C and cyclin E1, respectively. |
|
| Publications: |
1 |
| + |
CyclinE1/CDK3 | up-regulates 
|
G1/S_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273191 |
|
|
|
|
| pmid |
sentence |
| 37104883 |
Among them, CDK3 is critically important because it triggers the transitions of G0 to G1 and G1 to S phase through binding to cyclin C and cyclin E1, respectively. |
|
| Publications: |
1 |
| + |
CCNE1 | form complex
binding
|
CyclinE1/CDK3 |
0.754 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273186 |
|
|
|
|
| pmid |
sentence |
| 37104883 |
Among them, CDK3 is critically important because it triggers the transitions of G0 to G1 and G1 to S phase through binding to cyclin C and cyclin E1, respectively. |
|
| Publications: |
1 |
3.0
CyclinE1/CDK3