Relation Results

Summary

Name G1/S_transition
Primary ID SIGNOR-PH50
Type phenotype
Description Cell cycle G1/S phase transition: The cell cycle process by which a cell in G1 phase commits to S phase.
Relations 7
Pathways DNA repair in cancer, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Integrin Signaling, Luminal Breast Cancer, Malignant Melanoma, p53 in cancer, Pancreatic ductal adenocarcinoma (PDA)

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Type: Score: Layout: SPV 
0.70.70.70.70.70.70.7CyclinE/CDK2G1/S_transitionCCNA1E2F1RB1CyclinE1/CDK3DNA_replicationRIF1

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Relations
Regulator
Mechanism
target
score ℹ
+ CyclinE/CDK2up-regulates img/indirect-activation.png G1/S_transition 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-245480 Homo sapiens
pmid sentence
In its hypophosphorylated state, pRb binds transcription factors of the E2F family which are required for cell cycle progression. As the level of CyclinD/Cdk4/6 complexes increases, pRb becomes phosphorylated and progression through G1 occurs. At a critical level of phosphorylation, E2F is released from pRb. This activates the transcription of CyclinE which complexes with Cdk2 to fully release pRb repression by further phosphorylation, establishing a positive feedback loop. E2F further promotes the transcription of S-phase genes. Thus, CyclinD/Cdk4/6 and CyclinE/Cdk2 together regulate S-phase entry via phosphorylating pRb, which controls pRb binding to E2F
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Integrin Signaling, p53 in cancer
+ CCNA1up-regulates img/indirect-activation.png G1/S_transition 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-252255
pmid sentence
Cyclin A1 contributes to G1 to S cell cycle progression in somatic cells. Cyclin A1 overexpression enhances S phase entry consistent with an oncogenic function. Finally, cyclin A1 might be a therapeutic target since its silencing inhibited leukemia cell growth.
Publications: 1
+ E2F1up-regulates img/indirect-activation.png G1/S_transition 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-245477 Homo sapiens
pmid sentence
In its hypophosphorylated state, pRb binds transcription factors of the E2F family which are required for cell cycle progression. As the level of CyclinD/Cdk4/6 complexes increases, pRb becomes phosphorylated and progression through G1 occurs. At a critical level of phosphorylation, E2F is released from pRb. This activates the transcription of CyclinE which complexes with Cdk2 to fully release pRb repression by further phosphorylation, establishing a positive feedback loop. E2F further promotes the transcription of S-phase genes. Thus, CyclinD/Cdk4/6 and CyclinE/Cdk2 together regulate S-phase entry via phosphorylating pRb, which controls pRb binding to E2F
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Luminal Breast Cancer, Malignant Melanoma, Pancreatic ductal adenocarcinoma (PDA)
+ RB1down-regulates img/indirect_inhibition.png G1/S_transition 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-245483 Homo sapiens
pmid sentence
In its hypophosphorylated state, pRb binds transcription factors of the E2F family which are required for cell cycle progression. As the level of CyclinD/Cdk4/6 complexes increases, pRb becomes phosphorylated and progression through G1 occurs. At a critical level of phosphorylation, E2F is released from pRb. This activates the transcription of CyclinE which complexes with Cdk2 to fully release pRb repression by further phosphorylation, establishing a positive feedback loop. E2F further promotes the transcription of S-phase genes. Thus, CyclinD/Cdk4/6 and CyclinE/Cdk2 together regulate S-phase entry via phosphorylating pRb, which controls pRb binding to E2F
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Luminal Breast Cancer, Malignant Melanoma, p53 in cancer, Pancreatic ductal adenocarcinoma (PDA)
+ CyclinE1/CDK3up-regulates img/indirect-activation.png G1/S_transition 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-273191
pmid sentence
Among them, CDK3 is critically important because it triggers the transitions of G0 to G1 and G1 to S phase through binding to cyclin C and cyclin E1, respectively.
Publications: 1
+ G1/S_transitionup-regulates img/indirect-activation.png DNA_replication 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-245489 Homo sapiens
pmid sentence
In addition to the successive phosphorylation of pRb by active Cyclin/Cdk complexes, other factors can also impact upon S-phase entry Subsequently, the initiation of replication requires the formation of a pre-initiation complex (pre-IC) that is initiated by phosphorylation of Mcm2-7 by CyclinE/Cdk2 and DDK (Dbf4- and Drf1-dependent kinase) and recruitment of Cdc45 onto the chromatin (Figure 1). This recruitment is thought to be the critical step for the activation of the Mcm2-7 helicase activity and replication initiation. Finally, unwinding of the chromatin enables DNA-polymerase _ to initiate DNA synthesis and DNA-polymerase _ to continue replication
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ RIF1down-regulates img/indirect_inhibition.png G1/S_transition 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-259060 Homo sapiens
pmid sentence
This result would suggest that Rif1 acts in an intra-S-phase checkpoint pathway that is separate from the Nbs1 pathway. Although a role for human Rif1 at telomeres is not excluded, our data show that the primary function of Rif1 is in the DNA-damage response. Rif1 localizes to DSBs in an ATM- and 53BP1-dependent manner and functions in the intra-S-phase checkpoint that serves to slow down DNA synthesis when DNA damage has occurred.
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer
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