Relation Results

Summary

Name RBX1
Full Name E3 ubiquitin-protein ligase RBX1
Synonyms Protein ZYP, RING finger protein 75, RING-box protein 1, Rbx1, Regulator of cullins 1 | RNF75, ROC1
Primary ID P62877
Links - -
Type protein
Relations 11
Function E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subseque ...
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Type: Score: Layout: SPV 
0.4360.8660.2840.8330.8410.7960.9540.9290.3470.5980.2RBX1NFKB1DCX DET1-COP1NFKB2Cullin4-RBX1-DDB1Cullin 7-RBX1-Skp1VCB-Cul2Cullin 1-RBX1-Skp1Cullin 3-RBX1-Skp1ESR1BAF250b E3 ligaseUb:E2

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Relations
Regulator
Mechanism
target
score ℹ
+ RBX1up-regulates img/direct-activation.png ubiquitination NFKB1 0.436
Identifier Residue Sequence Organism Cell Line
SIGNOR-106781 Homo sapiens
pmid sentence
The scf-betatrcp complex is responsible for the ubiquitination of p100 and p105 following their phosphorylation by ikk.
Publications: 1 Organism: Homo Sapiens
+ RBX1form complex img/form-complex.png binding DCX DET1-COP1 0.866
Identifier Residue Sequence Organism Cell Line
SIGNOR-154511 Homo sapiens
pmid sentence
Mammalian det1 regulates cul4a activity and forms stable complexes with e2 ubiquitin-conjugating enzymes
Publications: 1 Organism: Homo Sapiens
+ RBX1up-regulates img/direct-activation.png ubiquitination NFKB2 0.284
Identifier Residue Sequence Organism Cell Line
SIGNOR-120342 Homo sapiens
pmid sentence
Mechanism of processing of the nf-kappa b2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of nedd8-modification on the scf(beta-trcp) ubiquitin ligase.
Publications: 1 Organism: Homo Sapiens
+ RBX1form complex img/form-complex.png binding Cullin4-RBX1-DDB1 0.833
Identifier Residue Sequence Organism Cell Line
SIGNOR-234799 Homo sapiens
pmid sentence
The CUL4 family employs the structurally distinct triple WD40 ²-propeller domain-containing DDB1 adaptor to recruit members of the DDB1€“CUL4 associated factors (DCAF) family of substrate receptors
Publications: 1 Organism: Homo Sapiens
+ RBX1form complex img/form-complex.png binding Cullin 7-RBX1-Skp1 0.841
Identifier Residue Sequence Organism Cell Line
SIGNOR-271626 Homo sapiens HCT-116 Cell
pmid sentence
FBXW8 associates with CUL1 or CUL7 and forms a complex with SKP1 and RBX1 
Publications: 1 Organism: Homo Sapiens
+ RBX1form complex img/form-complex.png binding VCB-Cul2 0.796
Identifier Residue Sequence Organism Cell Line
SIGNOR-271520 Homo sapiens
pmid sentence
The von Hippel-Lindau tumor-suppressor protein (pVHL) forms a protein complex (VCB-Cul2) with elongin C, elongin B, Cul-2, and Rbx1, which functions as a ubiquitin-protein ligase (E3). The alpha-subunits of the hypoxia-inducible factors have been identified as targets for the VCB-Cul2 ubiquitin ligase. 
Publications: 1 Organism: Homo Sapiens
+ RBX1form complex img/form-complex.png binding Cullin 1-RBX1-Skp1 0.954
Identifier Residue Sequence Organism Cell Line
SIGNOR-271629 Homo sapiens HCT-116 Cell
pmid sentence
FBXW8 associates with CUL1 or CUL7 and forms a complex with SKP1 and RBX1 
Publications: 1 Organism: Homo Sapiens
+ RBX1form complex img/form-complex.png binding Cullin 3-RBX1-Skp1 0.929
Identifier Residue Sequence Organism Cell Line
SIGNOR-271561 Homo sapiens HEK-293 Cell
pmid sentence
 KLHL12 recruits Dsh to Cullin-3 for protein degradation. In vitro ubiquitination of Dsh3 by KLHL12–Cullin-3–Roc1. The E3 ligase complex was obtained by transfection of HEK293T cells . We show that the BTB-containing protein KLHL12 negatively regulates Dsh function by recruiting a pool of Dsh to the Cullin-3 ligase scaffold, thereby promoting its ubiquitination and degradation.
Publications: 1 Organism: Homo Sapiens
+ RBX1down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination ESR1 0.347
Identifier Residue Sequence Organism Cell Line
SIGNOR-271434 Homo sapiens MCF-7 Cell
pmid sentence
I3C-dependent activation of the aryl hydrocarbon receptor (AhR) initiates Rbx-1 E3 ligase-mediated ubiquitination and proteasomal degradation of ERalpha protein.
Publications: 1 Organism: Homo Sapiens
+ RBX1form complex img/form-complex.png binding BAF250b E3 ligase 0.598
Identifier Residue Sequence Organism Cell Line
SIGNOR-271439 Homo sapiens HeLa Cell
pmid sentence
In the present work, we show that BAF250 associates with elongin C (Elo C), cullin 2 (Cul2), and Roc1 to form an E3 ubiquitin ligase. BAF250 forms an E3 ubiquitin ligase with Elo B/C, Cul2, and Roc1 that targets histone H2B. H2B-Ub has been shown to be required for transcriptional activation in vitro
Publications: 1 Organism: Homo Sapiens
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination RBX1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270993 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t
Publications: 1 Organism: Homo Sapiens
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