| + |
MLH1 | form complex 
binding
|
MLH1/PMS2 |
0.758 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-71771 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10542278 |
Hmlh1 and hpms2 function in postreplicative mismatch repair in the form of a heterodimer referred to as hmutl_ |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DNA_damage | up-regulates 
|
MLH1/PMS2 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259062 |
|
|
in vitro |
|
| pmid |
sentence |
| 10542278 |
HMLH1 and hPMS2 function in postreplicative mismatch repair in the form of a heterodimer referred to as hMutLα. Tumors or cell lines lacking this factor display mutator phenotypes and microsatellite instability, and mutations in the hMLH1 andhPMS2 genes predispose to hereditary non-polyposis colon cancer. Recombinant hMutLα and hMutLβ, expressed in the baculovirus system, were tested for their activity in an in vitro mismatch repair assay. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | DNA repair in cancer |
| + |
PMS2 | form complex
binding
|
MLH1/PMS2 |
0.758 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-71777 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10542278 |
Hmlh1 and hpms2 function in postreplicative mismatch repair in the form of a heterodimer referred to as hmutl_ |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MLH1/PMS2 | up-regulates activity
|
DNA_repair |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-257600 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 29175432 |
MLH1 and PMS2 proteins form the MutLα heterodimer, which plays a major role in DNA mismatch repair (MMR) in humans |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | DNA repair in cancer |
4.0
MLH1/PMS2