+ |
MLH1 | form complex
binding
|
MLH1/PMS2 |
0.759 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-71771 |
|
|
Homo sapiens |
|
pmid |
sentence |
10542278 |
Hmlh1 and hpms2 function in postreplicative mismatch repair in the form of a heterodimer referred to as hmutl_ |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TP53 | up-regulates quantity
transcriptional regulation
|
MLH1 |
0.608 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-257605 |
|
|
Homo sapiens |
|
pmid |
sentence |
15781865 |
.... numerous potentially novel targets, including the DNA mismatch repair genes MLH1 and PMS2. Both of these genes were determined to be responsive to DNA damage and p53 activation in normal human fibroblasts, and have p53-response elements within their first intron. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MLH1 | up-regulates activity
|
DNA_repair |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-257595 |
|
|
Mus musculus |
|
pmid |
sentence |
9500552 |
Germline mutations in the human MSH2, MLH1, PMS2 and PMS1 DNA mismatch repair (MMR) gene homologues appear to be responsible for most cases of hereditary non-polyposis colorectal cancer |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
ABL1 | up-regulates quantity by stabilization
phosphorylation
|
MLH1 |
0.344 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-279581 |
|
|
Homo sapiens |
|
pmid |
sentence |
36338985 |
We also observed phosphorylation of MLH1 by ABL1 in an in vitro kinase assay with purified recombinant ABL1 and MLH1, confirming there is a direct phosphorylation between ABL1 and the MLH1 component of the MLH1-PMS2 heterodimer.|we propose that ABL1 prevents MLH1 from being targeted for degradation by the chaperone Hsp70 and that in the absence of ABL1 activity at least a portion of MLH1 is degraded. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MLH1 | form complex
binding
|
MLH1/PMS1 |
0.694 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-71768 |
|
|
Homo sapiens |
|
pmid |
sentence |
10542278 |
We now show that hpms1 is expressed in human cells and that it interacts with hmlh1 with high affinity to form the heterodimer hmutl_. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |