| + |
STAT5A | up-regulates 
|
Erythrocyte_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256074 |
|
|
Homo sapiens |
Culture Condition:CD34+ Cell |
| pmid |
sentence |
| 15353555 |
Here we report that a persistent activation of STAT5A in human CD34+ cells results in enhanced self-renewal. STAT5A drives the expression of a number of proto-oncogenes and cytokines in human CD34+ cells, as well as a number of erythroid-specific genes, favoring erythroid over myeloid differentiation and providing a long-term proliferative advantage for erythroid progenitors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF1 | up-regulates
|
Erythrocyte_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256086 |
|
|
Homo sapiens |
Hematopoietic Stem Cell |
| pmid |
sentence |
| 28026072 |
Activation of KLF1 at day 10 of the differentiation process when hematopoietic progenitor cells were present, enhanced erythroid commitment and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
GATA1 | up-regulates activity
|
Erythrocyte_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259962 |
|
|
Mus musculus |
Erythroid Progenitor Cell |
| pmid |
sentence |
| 12032775 |
The zinc finger transcription factor GATA-1, a central mediator of erythroid gene expression, interacts with multiple proteins including FOG-1, EKLF, SP1, CBP/p300 and PU.1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
TAL1 | up-regulates activity
|
Erythrocyte_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259971 |
|
|
Mus musculus |
Erythroid Progenitor Cell |
| pmid |
sentence |
| 23319051 |
Analysis of SclΔ40/Δ40 embryonic stem (ES) cells revealed impaired erythroid differentiation, which was accompanied by a failure to upregulate Scl when erythropoiesis was initiated. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259970 |
|
|
Mus musculus |
Erythroid Progenitor Cell |
| pmid |
sentence |
| 29713515 |
The truncated form TAL1-s is required for erythroid progenitors differentiation, while the full-length protein TAL1-l is required for megakaryocytic differentiation of progenitor cells. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
ZFPM1 | up-regulates activity
|
Erythrocyte_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259964 |
|
|
Mus musculus |
Hematopoietic Stem Cell |
| pmid |
sentence |
| 22068055 |
We here use conditional removal of the GATA-1 and FOG-1 transcription factors to identify FOG-1 as required for the formation of all committed Mk- and E-lineage progenitors, whereas GATA-1 was observed to be specifically required for E-lineage commitment. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | HaematopoiesisTranscriptionalControl |
3.0
Erythrocyte_differentiation