| + |
Actin_cytoskeleton_reorganization | up-regulates 
|
Axonal_growth_cone_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268383 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 21106647 |
Axon outgrowth and guidance to the proper target requires the coordination of filamentous (F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape change and locomotion. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268384 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 21106647 |
Axon outgrowth and guidance to the proper target requires the coordination of filamentous (F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape change and locomotion. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Axon guidance |
| + |
F-actin_assembly | up-regulates
|
Axonal_growth_cone_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268387 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 21106647 |
Axon outgrowth and guidance to the proper target requires the coordination of filamentous (F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape change and locomotion. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Axon guidance |
| + |
DSCAM | up-regulates
|
Axonal_growth_cone_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268396 |
|
|
Rattus norvegicus |
Neuron |
| pmid |
sentence |
| 18585357 |
DSCAM is required for commissural axon guidance in vivo. DSCAM promotes axonal growth but is dispensable for cell body migration and for axon turning toward a local source of netrin-1 in whole spinal cord turning assays. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268401 |
|
|
Rattus norvegicus |
Neuron |
| pmid |
sentence |
| 18585357 |
DSCAM is required for commissural axon guidance in vivo. DSCAM promotes axonal growth but is dispensable for cell body migration and for axon turning toward a local source of netrin-1 in whole spinal cord turning assays. |
|
| Publications: |
2 |
Organism: |
Rattus Norvegicus |
| Pathways: | Axon guidance |
| + |
ENAH | up-regulates
|
Axonal_growth_cone_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268389 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18508258 |
Here we review recent findings into Ena/VASP function in neurite initiation, axon outgrowth and guidance. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Axon guidance |
| + |
CFL1 | down-regulates 
|
Axonal_growth_cone_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268382 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16226035 |
This observation suggests that Slit2 may require the Robo2 and Robo3 receptors in this process . Slit2 causes the miRNA miR-182 to release cofilin1 mRNA, potentiating cofilin1 local translation and resulting in growth cone collapse. The use of morpholinos or RNAi to knockdown robo2 and robo3 in X. laevis RGCs, would be useful to further confirm that Robo2 and Robo3 are the receptors involved in Slit2-dependent cofilin1 translation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Axon guidance |
| + |
MYO10 | up-regulates
|
Axonal_growth_cone_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268284 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27580874 |
Myosin X is required for filopodia formation and extension. myosin X functions as an antiparallel dimer in cells with a unique geometry optimized for movement on actin bundles. Myosin X facilitates initiation and elongation of filopodia, which implies favouring formation of parallel bundled F-actin filaments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Axon guidance |
| + |
VASP | up-regulates
|
Axonal_growth_cone_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268390 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18508258 |
Here we review recent findings into Ena/VASP function in neurite initiation, axon outgrowth and guidance. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Axon guidance |
| + |
EVL | up-regulates
|
Axonal_growth_cone_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268391 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18508258 |
Here we review recent findings into Ena/VASP function in neurite initiation, axon outgrowth and guidance. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Axon guidance |
3.0
Axonal_growth_cone_formation