+ |
LAG3 | up-regulates
|
T cell exhaustion |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275414 |
|
|
Homo sapiens |
T-lymphocyte |
pmid |
sentence |
27192565 |
Lag-3, Tim-3, and TIGIT are highly expressed on dysfunctional or exhausted T cells in chronic diseases such as chronic viral infection and cancer. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PDCD1 | up-regulates
|
T cell exhaustion |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275413 |
|
|
Homo sapiens |
T-lymphocyte |
pmid |
sentence |
28286692 |
Programmed cell death-1 (PD-1) is a major regulator of T-cell exhaustion, and blocking the PD-1 pathway restores T-cell function and improves pathogen control and tumor eradication. Immunotherapy targeting the PD-1 inhibitory receptor pathway has demonstrated significant antitumor activity. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CTLA4 | up-regulates
|
T cell exhaustion |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275415 |
|
|
Homo sapiens |
T-lymphocyte |
pmid |
sentence |
26086965 |
Both PD-1 and CTLA-4 inhibited the activity of Akt, a crucial molecular in regulating glucose metabolism of T cells by elevating glucose transporter 1 expression and glycolysis, suggesting that glucose metabolism may contribute to T-cell exhaustion |
|
Publications: |
1 |
Organism: |
Homo Sapiens |