| + |
PIP3 | up-regulates 
|
Macropinosomes formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277769 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 29572236 |
PIP3 produced by type I PI3Ks is required for macropinosome closure; in some cell types, PIP3 is also required for membrane ruffling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Macropinosomes formation | up-regulates 
|
Early macropinosomes |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277775 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33722976 |
Completion of macropinosome formation requires membrane fusion and is followed by maturation of the resulting vacuole, which proceeds to merge with endosomes and, ultimately, lysosomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
F-actin_assembly | up-regulates
|
Macropinosomes formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277767 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 39000072 |
The signaling for the regulation of macropinocytosis normally starts with the activation of RAS protein by macropinocytic stimulators, which in turn initiate signaling cascades involving RAC1 and phosphatidylinositol kinases and their downstream effectors or product that lead to actin cytoskeleton remodeling for plasma membrane ruffle and macropinocytic cup formation. Macropinosomes are further matured by regulation of the small GTPases RAC1 and CDC42 as well as phosphatidylinositol lipids, and matured macropinosomes undergo recycling or degradation processes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Macropinosomes formation