| + |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | down-regulates 
|
Early macropinosomes |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277774 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33722976 |
We report that Rab5 acts at the plasma membrane, downstream of ruffling, to promote macropinosome sealing and scission. Rab5 is recruited to plasmalemmal circular ruffles before macropinosome closure. The mammalian 5-phosphatases Inpp5b and OCRL, which can degrade PtdIns(4,5)P2, are both Rab5-associating effectors implicated in endocytosis and macropinocytosis. These observations raised the possibility that PtdIns(4,5)P2 depletion is in fact required for the completion of macropinocytosis or to prevent macropinosome back-fusion with the plasmalemma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Macropinosomes formation | up-regulates 
|
Early macropinosomes |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277775 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33722976 |
Completion of macropinosome formation requires membrane fusion and is followed by maturation of the resulting vacuole, which proceeds to merge with endosomes and, ultimately, lysosomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB21 | up-regulates 
binding
|
Early macropinosomes |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277782 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19693279 |
It was demonstrated that wild-type Rab21 was transiently associated with macropinosomes. Rab21 was recruited to the macropinosomes after a decrease in PI(4,5)P(2) and PI(3,4,5)P(3) levels. Although Rab21 was largely colocalized with Rab5, the recruitment of Rab21 to the macropinosomes lagged a minute behind that of Rab5, and preceded that of Rab7. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Early macropinosomes