| + |
RAB7A | up-regulates 
|
Late macropinosomes |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277779 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19693279 |
Rab7 is localized on later macropinosomes. Rab21 is localized on macropinosomes at an intermediate stage partially overlapping with Rab5 and Rab7, and then dissociates from the macropinosomes prior to Lamp1 acquisition by fusing with lysosomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Early macropinosomes | up-regulates
|
Late macropinosomes |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277789 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 39000072 |
The early macropinosomes continue to mature into late macropinosomes, which fuse with lysosomes and degrade their cargos. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Late macropinosomes | up-regulates
|
Lysosome fusion |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277787 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 39000072 |
The fusion of matured macropinosomes with lysosomes is promoted by TRPML1, and degradation of macropinosomes is inhibited by mTORC1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Late macropinosomes