| + |
STAT3 | up-regulates 
|
PDAC-associated neural remodeling (PANR) |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278038 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 29269518 |
Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive stroma and pathogenic modifications to the peripheral nervous system that elevate metastatic capacity. In this study, we show that the IL6-related stem cell–promoting factor LIF supports PDAC-associated neural remodeling (PANR).Biological investigations showed that LIF promoted the differentiation of glial nerve sheath Schwann cells and induced their migration by activating JAK/STAT3/AKT signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT | up-regulates
|
PDAC-associated neural remodeling (PANR) |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278039 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 29269518 |
Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive stroma and pathogenic modifications to the peripheral nervous system that elevate metastatic capacity. In this study, we show that the IL6-related stem cell–promoting factor LIF supports PDAC-associated neural remodeling (PANR).Biological investigations showed that LIF promoted the differentiation of glial nerve sheath Schwann cells and induced their migration by activating JAK/STAT3/AKT signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PDAC-associated neural remodeling (PANR)