| + |
DAXX | down-regulates
|
Immortality |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256596 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 26428317 |
Telomere length must be maintained for the immortalization of malignant cells […] alternative lengthening of telomeres status was perfectly correlated with the loss of expression of either α-thalassemia/mental retardation syndrome X-linked (ATRX) or death domain-associated (DAXX) protein in pancreatic neuroendocrine tumors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDKN2A | down-regulates
|
Immortality |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259286 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10648628 |
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Pancreatic ductal adenocarcinoma (PDA) |
| + |
TERT | up-regulates
|
Immortality |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252292 |
|
|
|
|
| pmid |
sentence |
| 11327115 |
Telomerase is tightly repressed in the vast majority of normal human somatic cells but becomes activated during cellular immortalization and in cancers |
|
| Publications: |
1 |
| Pathways: | Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA) |
| + |
ATRX | down-regulates
|
Immortality |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256595 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 26428317 |
Telomere length must be maintained for the immortalization of malignant cells […] alternative lengthening of telomeres status was perfectly correlated with the loss of expression of either α-thalassemia/mental retardation syndrome X-linked (ATRX) or death domain-associated (DAXX) protein in pancreatic neuroendocrine tumors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |