| + |
Cytoplasmic_Dynein | up-regulates 
|
Organelle_transport |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265058 |
|
|
|
|
| pmid |
sentence |
| 16440056 |
The most abundant cytoplasmic dynein complex, cytoplasmic dynein 1, is involved in functions as diverse as spindle-pole organization and nuclear migration during mitosis, the positioning and functioning of the endoplasmic reticulum, the Golgi apparatus, and the nucleus, and also the minus-end-directed transport of vesicles, including endosomes and lysosomes, along microtubules and retrograde axonal transport in neurons. |
|
| Publications: |
1 |
| + |
DCTN2 | up-regulates activity 
relocalization
|
Cytoplasmic_Dynein |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265018 |
|
|
|
|
| pmid |
sentence |
| 25364732 |
ZW10 interacts with dynamitin, a subunit of the dynein-dynactin complex (Echeverri et al., 1996), thereby recruiting this motor to kinetochores |
|
| Publications: |
1 |
| + |
Cytoplasmic_Dynein | up-regulates
|
Cilium_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265022 |
|
|
|
|
| pmid |
sentence |
| 16440056 |
A second cytoplasmic dynein complex, cytoplasmic dynein 2, has a role in intraflagellar transport (IFT), a process required for ciliary/flagellar assembly |
|
| Publications: |
1 |
| + |
Cytoplasmic_Dynein | up-regulates
|
Spindle_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265059 |
|
|
|
|
| pmid |
sentence |
| 16440056 |
The most abundant cytoplasmic dynein complex, cytoplasmic dynein 1, is involved in functions as diverse as spindle-pole organization and nuclear migration during mitosis, the positioning and functioning of the endoplasmic reticulum, the Golgi apparatus, and the nucleus, and also the minus-end-directed transport of vesicles, including endosomes and lysosomes, along microtubules and retrograde axonal transport in neurons. |
|
| Publications: |
1 |
| + |
Cytoplasmic_Dynein | up-regulates
|
Microtubule-based_movement |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265019 |
|
|
|
|
| pmid |
sentence |
| 16440056 |
Dyneins are large multi-subunit protein complexes that undertake a wide range of roles within the cell. They are adenosine triphosphate (ATP)–driven, microtubule minus-end-directed molecular motors that can be divided, based on function, into two classes: axonemal and cytoplasmic dyneins |
|
| Publications: |
1 |
3.0
Cytoplasmic_Dynein