| + |
NPNT | up-regulates 
|
Myoblast_fusion |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255458 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23612709 |
The MEK5-dependent activation of ERK5 promotes binding of the transcription factor SP1 to the promoter of the genes encoding the transcription factors Klf2 and Klf4, leading to their increased abundance. Subsequently, Klf2 and Klf4 bind to the Npnt promoter and induce the production of nephronectin during myoblast fusion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYOF | up-regulates
|
Myoblast_fusion |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255973 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16280346 |
These data support a role for myoferlin in the maturation of myotubes and the formation of large myotubes that arise from the fusion of myoblasts to multinucleate myotubes |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255466 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23612709 |
Activated NFATc2 stimulates myoblast fusion through the increased production of IL-4 and myoferlin |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| + |
prostaglandin F2alpha | up-regulates
|
Myoblast_fusion |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256213 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20219869 |
Prostaglandins are able to affect muscle cell proliferation (142), differentiation (96) and fusion (141), and can also modulate muscle fiber growth and the synthesis and degradation of proteins in muscle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAMK2D | up-regulates
|
Myoblast_fusion |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255955 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19725819 |
In the cytoplasm where the activated CaMKII localises it induces signalling pathways that are mainly involved in mitochondrial biogenesis and expression of contractile protein |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL4 | up-regulates
|
Myoblast_fusion |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255896 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12757709 |
These data demonstrate that following myotube formation, myotubes recruit myoblast fusion by secretion of IL-4, leading to muscle growth |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MEF2A | up-regulates
|
Myoblast_fusion |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255957 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19725819 |
In response to increases in intracellular Ca2+ levels, activated CaMKII translocates into the nucleus where it phosphorylates and deactivates HDAC4 which, as a result, dissociates from theDNA-binding domain of MEF2. This dissociation allows MEF2 to bind to its DNA-binding domain to activate transcription of the MEF2-dependent target gene products MyoD and myogenin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Myoblast_fusion