| + |
IL4 | up-regulates 
binding
|
IL4R |
0.941 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100762 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12704343 |
IL-4R Is a 140-kd protein that binds il-4 with high affinity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67217 |
|
|
in vitro |
|
| pmid |
sentence |
| 10219247 |
Nterleukin-4 (il-4) is a principal regulatory cytokine during an immune response and a crucial determinant for allergy and asthma. Il-4 binds with high affinity and specificity to the ectodomain of the il-4 receptor alpha chain (il4-bp). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, In Vitro |
| Pathways: | Macrophage polarization, Multiple sclerosis |
| + |
M2_polarization | up-regulates 
|
IL4 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263822 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 32454942 |
Macrophages and microglia show a high plasticity and have been arbitrarily classified into “M1” (proinflammatory) and “M2” (prorepair, anti-inflammatory) phenotypes depending on their activation state, although it is now widely accepted that this classification is hugely oversimplified, particularly for microglia, and only partially reflects the real situation. M2 polarized cells express a variety of anti-inflammatory mediators, such as IL-4, IL-10, and transforming growth factor-β (TGF-β), and contribute to immunoregulation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization, Multiple sclerosis |
| + |
JUNB | up-regulates quantity by expression
transcriptional regulation
|
IL4 |
0.47 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254503 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 21799768 |
Our results suggest that the prolonged IL-4 expression in NFAT1 deficient Th2 cells is mediated by preferential binding of JUNB/SATB1 to the IL-4 promoter with permissive chromatin architecture |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NfKb-p65/p50 | up-regulates quantity by expression
transcriptional regulation
|
IL4 |
0.418 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254497 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 15048722 |
We demonstrate that NF-kappa B binds to the IL-4 promoter in vivo upon T cell activation. Inhibition of NF-kappa B nuclear translocation in living cells blocked binding of NF-kappa B to the IL-4 promoter. The data provide first evidence that NF-kappa B is directly involved in IL-4 transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization, Multiple sclerosis |
| + |
POU2F1 | down-regulates quantity by repression 
transcriptional regulation
|
IL4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254505 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 11781715 |
Here we show that NFAT proteins are unable to bind to a combined octamer/NFAT site unless the octamer proteins are competed away |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTGS2 | up-regulates
|
IL4 |
0.458 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255967 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22225874 |
Cox2 Is a Direct Srf Target Gene and Controls Il4 Expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Inflammation | up-regulates
|
IL4 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255494 |
|
|
Homo sapiens |
Eosinophil |
| pmid |
sentence |
| 11290754 |
Our findings indicate that chemokines acting via CCR3-initiated signaling pathways can very rapidly mobilize preformed stores of IL-4 from within human eosinophils. The means of extracellular release was by noncytotoxic, vesicular transport |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Multiple sclerosis |
| + |
CIITA | down-regulates
transcriptional regulation
|
IL4 |
0.417 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254499 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 10946277 |
We identified two domains of CIITA that interact with two distinct domains of CBP/p300 that are also recognized by NF-AT. CIITA mutants that retain the ability to interact with CBP/p300 are sufficient to inhibit NF-AT-mediated IL-4 gene expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL4 | up-regulates activity
binding
|
IL4R |
0.941 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249527 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 18852293 |
IL-4 signals through the type I (IL-4Ralpha/common gamma-chain [gammac]) and the type II (IL-4Ralpha/-13Ralpha1) IL-4 receptors, whereas IL-13 utilizes only the type II receptor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization, Multiple sclerosis |
| + |
GATA3 | up-regulates quantity by expression
transcriptional regulation
|
IL4 |
0.503 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254500 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 12876556 |
Initiation of transcription of the gene encoding IL-4 in naive T(H) cells is regulated by the T(H) 2-specific transcription factor GATA3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFATC2 | up-regulates
transcriptional regulation
|
IL4 |
0.525 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255460 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23612709 |
Activated NFATc2 stimulates myoblast fusion through the increased production of IL-4 and myoferlin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL4 | up-regulates
|
Myoblast_fusion |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255896 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12757709 |
These data demonstrate that following myotube formation, myotubes recruit myoblast fusion by secretion of IL-4, leading to muscle growth |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
IL4 | up-regulates
binding
|
IL2RG |
0.853 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-108861 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11418623 |
The common gamma-chain (gamma(c)) is an indispensable subunit of the functional receptor complexes for il-4, il-7, il-9, and il-15 as well as il-2. Here we show that the gamma(c) is also shared with the il-21r complex |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LEF1 | down-regulates quantity by repression
transcriptional regulation
|
IL4 |
0.358 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254504 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 18579517 |
We identified a high affinity LEF-1-binding site in the negative regulatory element of the IL-4 promoter. Knockdown LEF-1 expression by LEF-1-specific small interfering RNA resulted in an increase in the IL-4 mRNA expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFATC1 | up-regulates quantity by expression
transcriptional regulation
|
IL4 |
0.531 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254498 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8668213 |
Recombinant NFAT1 can mediate transcription of the interleukin-2, interleukin-4, tumor necrosis factor alpha, and granulocyte-macrophage colony-stimulating factor promoters in T cells, suggesting that NFAT1 contributes to the CsA-sensitive transcription of these genes during the immune response. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TBX21 | down-regulates
transcriptional regulation
|
IL4 |
0.493 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254496 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 17541280 |
IL-4 gene transcription is inhibited by T-bet via the suppression of its promoter activity, independently of IFN-gamma. T-bet facilitates Th1 differentiation through not only upregulation of IFN-gamma, but also downregulation of IL-4 gene transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFATC2 | up-regulates quantity by expression
transcriptional regulation
|
IL4 |
0.525 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254502 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 11956291 |
IRF4 synergizes with NFATc2 and the IL-4-inducing transcription factor, c-maf, to augment IL-4 promoter activity as well as to elicit significant levels of endogenous IL-4 production |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL4 | up-regulates
binding
|
IL13RA1 |
0.772 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100759 |
|
|
Homo sapiens |
T-lymphocyte, Macrophage, Monocyte |
| pmid |
sentence |
| 12704343 |
It is now known that this alternate receptor is a heterodimer, the type ii il-4 receptor or the il-13 receptor, which is comprised of IL-4R And IL-13R1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Lung, Smooth Muscle |
| + |
IRF4 | up-regulates quantity by expression
transcriptional regulation
|
IL4 |
0.541 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254501 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 11956291 |
IRF4 synergizes with NFATc2 and the IL-4-inducing transcription factor, c-maf, to augment IL-4 promoter activity as well as to elicit significant levels of endogenous IL-4 production |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization |
3.0
IL4
- 
- 