| + |
ERK1/2 | up-regulates 
|
Macrophage_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255573 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24890514 |
The Erk1/2 pathway has a central role in CSF-1R-regulated myeloid differentiation. CSF-1 induces early (peaking at ∼5 min) and persistent (starting at 1 h) waves of MEK/Erk1/2 phosphorylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETS2 | up-regulates
|
Macrophage_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259871 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11175361 |
the constitutive expression of ets2 in myeloblast leukemic cells induces their differentiation to macrophages |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
S100A9 | down-regulates 
|
Macrophage_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261933 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18809714 |
We report here that up-regulation of S100A9 in myeloid precursors in cancer inhibits DC and macrophage differentiation and induces accumulation of MDSCs. This may represent a universal molecular mechanism of tumor-induced abnormalities in myeloid cells in cancer, directly linking inflammation and immune suppression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PLCG2 | up-regulates
|
Macrophage_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255571 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24890514 |
Studies with multipotent precursor cell lines (Fig. 4A) indicate that CSF-1R Tyr-807 and Tyr-721 promote macrophage differentiation via the PLC-γ2 pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Macrophage_differentiation