Mitochondrial Control of Apoptosis

Pathway ID: SIGNOR-MCAPO View in NDEx

Description: Apoptosis is a type of programmed cell death that allows the maintenance of cellular homeostasis. Mitochondrial membrane permeabilization represents a critical step in the regulation of intrinsic apoptosis, process that is mainly regulated by members of the Bcl2 family of proteins that can act as pro- or anti-apoptotic factors.

Curated by: Alessandra Silvestri

SIGNOR Cytoscape App Use SIGNOR Cytoscape App

26 Seed Entities

Organism:
Name Primary ID
DNA_damage SIGNOR-ST1
PARP1 P09874
BCL2 P10415
FAS P25445
BAD Q92934
Apoptosis SIGNOR-PH2
TNFRSF1A P19438
BCL2L1 Q07817
CASP8 Q14790
Survival Factors SIGNOR-ST8
APAF1 O14727
FADD Q13158
CASP9 P55211
CASP3 P42574
TRADD Q15628
BBC3 Q9BXH1
BID P55957
CYCS P99999
TP53 P04637
FASLG P48023
BAX Q07812
RIPK1 Q13546
TNF P01375
NOXA1 Q86UR1
BCL2L11 O43521
ER stress SIGNOR-ST9