Mitochondrial Control of Apoptosis

Pathway ID: SIGNOR-MCAPOView in NDEx

Description: Apoptosis is a type of programmed cell death that allows the maintenance of cellular homeostasis. Mitochondrial membrane permeabilization represents a critical step in the regulation of intrinsic apoptosis, process that is mainly regulated by members of the Bcl2 family of proteins that can act as pro- or anti-apoptotic factors.

Curated by: Alessandra Silvestri

26 Seed Entities

Organism:
Name Primary ID
DNA_damage SIGNOR-ST1
PARP1 P09874
BCL2 P10415
BAD Q92934
BCL2L1 Q07817
CASP9 P55211
CYCS P99999
BAX Q07812
RIPK1 Q13546
TNF P01375
NOXA1 Q86UR1
BCL2L11 O43521
ER stress SIGNOR-ST9
FAS P25445
Apoptosis SIGNOR-PH2
TNFRSF1A P19438
CASP8 Q14790
Survival Factors SIGNOR-ST8
APAF1 O14727
FADD Q13158
CASP3 P42574
TRADD Q15628
BBC3 Q9BXH1
BID P55957
TP53 P04637
FASLG P48023