| + |
glucose | up-regulates quantity by stabilization 
|
Hexokinase |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270265 |
|
|
Homo sapiens |
ES-2 Cell |
| pmid |
sentence |
| 26323688 |
Consistently, treatment of cells with 2-deoxy-d-glucose (2DG), which completely inhibits glucose metabolism, leads to HK2 degradation and cell death in combination with C43 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glucose | down-regulates activity 
|
AMPK |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256137 |
|
|
Mus musculus |
Myoblast |
| pmid |
sentence |
| 18477450 |
Glucose restriction (GR) impaired differentiation of skeletal myoblasts and was associated with activation of the AMP-activated protein kinase (AMPK). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, IDH-TET in AML |
| + |
glucose | down-regulates activity 
chemical inhibition
|
AMPK |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277765 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32745890 |
Glucose deprivation, activates the glucose level–sensing kinase, AMPK, which in turn influences Rac1-dependent macropinocytosis. In this context macropinosomes take up necrotic cell debris as a rich nutrient source to fuel tumor cell growth |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, IDH-TET in AML |
| + |
SLC2A4 | up-regulates quantity
relocalization
|
glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267288 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17403369 |
Skeletal muscle both stores glucose as glycogen and oxidizes it to produce energy following the transport step. The principal glucose transporter protein that mediates this uptake is GLUT4, which plays a key role in regulating whole body glucose homeostasis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC2A3 | up-regulates quantity
relocalization
|
glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267461 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23506862 |
GLUThe SLC2A3 gene encoding GLUT3 was first cloned from a human fetal skeletal muscle cell line (Kayano et al., 1988). It shares ~64% sequence identity with SLC2A1. GLUT3 has a higher apparent affinity (lower Km) and a higher maximum turnover number for glucose than the other Class 1 GLUT proteins, and its principal physiological substrate is clearly D-glucose T1 plays a critical role in cerebral glucose uptake as the major GLUT isoform expressed in brain endothelial cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC2A2 | up-regulates quantity
relocalization
|
glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267386 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25421524 |
The glucose transporter isoform GLUT2 is expressed in liver, intestine, kidney and pancreatic islet beta cells, as well as in the central nervous system, in neurons, astrocytes and tanycytes. Physiological studies of genetically modified mice have revealed a role for GLUT2 in several regulatory mechanisms. In pancreatic beta cells, GLUT2 is required for glucose-stimulated insulin secretion. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAS1R2-TAS1R3 type 1 taste receptor complex | up-regulates activity
binding
|
glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281448 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40339580 |
The receptor, composed of two GPCR subunits, one unique (TAS1R2) and one shared with the umami receptor (TAS1R3), has the essential role of detecting and driving appetitive and consummatory responses to the most basic sources of metabolic energy (e.g., glucose, sucrose, lactose, and other sugars). Future studies determining the structure of the sweet receptor in the presence of sucrose, glucose, lactose, and other natural sugars will help uncover the nature of the interactions between the TAS1R2 VFT and sugars, further highlighting the evolutionary refinement and functional versatility of the binding pocket in accommodating such a wide range of millimolar-affinity ligands. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAS1R1-TAS1R3 type 1 taste receptor complex | up-regulates activity
binding
|
glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281449 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40339580 |
The receptor, composed of two GPCR subunits, one unique (TAS1R2) and one shared with the umami receptor (TAS1R3), has the essential role of detecting and driving appetitive and consummatory responses to the most basic sources of metabolic energy (e.g., glucose, sucrose, lactose, and other sugars). Future studies determining the structure of the sweet receptor in the presence of sucrose, glucose, lactose, and other natural sugars will help uncover the nature of the interactions between the TAS1R2 VFT and sugars, further highlighting the evolutionary refinement and functional versatility of the binding pocket in accommodating such a wide range of millimolar-affinity ligands. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC2A1 | up-regulates quantity
relocalization
|
glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267460 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23506862 |
GLUT1 plays a critical role in cerebral glucose uptake as the major GLUT isoform expressed in brain endothelial cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glucose | up-regulates quantity by stabilization
|
HK2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261323 |
|
|
Homo sapiens |
ES-2 Cell |
| pmid |
sentence |
| 26323688 |
Consistently, treatment of cells with 2-deoxy-d-glucose (2DG), which completely inhibits glucose metabolism, leads to HK2 degradation and cell death in combination with C43 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glucose | down-regulates activity
|
PRKAA1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256136 |
|
|
Mus musculus |
Myoblast |
| pmid |
sentence |
| 18477450 |
Glucose restriction (GR) impaired differentiation of skeletal myoblasts and was associated with activation of the AMP-activated protein kinase (AMPK). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
4.0
glucose
