Relation Results

Summary

Name 3,3',5'-triiodothyronine
Synonyms 3,3',5'-Triiodothyronine (KEGG COMPOUND), 4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenylalanine (IUPAC), O-(4-hydroxy-3,5-diiodophenyl)-3-iodotyrosine (IUPAC), Reverse triiodothyronine (ChemIDplus), Triiodothyronine, reverse (KEGG COMPOUND)
IUPAC
Formula
Primary ID CHEBI:28774
Type small molecule
Relations 23
Pathways Thyroid Hormone Metabolism

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Type: Score: Layout: SPV 
0.80.80.70.80.80.80.80.80.70.80.80.70.80.80.80.7DIO3,3',5'-triiodothyronineTHRBThermogenesis DIO1TPO3-iodo-L-tyrosineL-thyroxineFatty_Acid_BiosynthesisTHRA3,5-diiodo-L-tyrosineSkeletal_muscle_differentiationDIO3SLC16A2THRGluconeogenesis

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Relations
Regulator
Mechanism
target
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+ DIOup-regulates quantity img/direct-activation.png chemical modification 3,3',5'-triiodothyronine 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267809 Homo sapiens
pmid sentence
The deiodinase family of enzymes controls the tissue-specific activation and inactivation of the prohormone thyroxine (T4)
Identifier Residue Sequence Organism Cell Line
SIGNOR-267044 Homo sapiens
pmid sentence
Thyroid hormone (TH) deiodinases play a pivotal role in the functional diversification of TH signaling. They are involved in development, growth, and metabolic processes, and act in a cell-specific manner in the fine regulation of TH homeostasis. TH deiodinases catalyze activation and inactivation of THs through the removal of one iodine atom in the outer or inner ring of the TH molecule. 
Publications: 2 Organism: Homo Sapiens
+ 3,3',5'-triiodothyronineup-regulates activity img/direct-activation.png binding, chemical activation THRB 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267254 Homo sapiens
pmid sentence
T3 binds its receptor (TR) in the nucleus. TRs are ligand-dependent transcription factors belonging to the type II group of NHRs. TRs are encoded by two genes, Thra and Thrb.
Identifier Residue Sequence Organism Cell Line
SIGNOR-258384 Rattus norvegicus Liver
pmid sentence
We determined the affinity for T3 and analog binding characteristics of the translational products of c-erbA a- and /3-probes together with hepatic nuclear extracts.
Publications: 2 Organism: Homo Sapiens, Rattus Norvegicus
Tissue: Hypophysis
Pathways:Thyroid Hormone Metabolism
+ 3,3',5'-triiodothyronineup-regulates img/indirect-activation.png Thermogenesis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-267491 Homo sapiens
pmid sentence
TH plays a significant role in energy expenditure through both central and peripheral actions. TH maintains basal metabolic rate, facilitates adaptive thermogenesis, modulates appetite and food intake, and regulates body weight.
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ DIO1up-regulates quantity img/direct-activation.png chemical modification 3,3',5'-triiodothyronine 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266945 Homo sapiens
pmid sentence
The type I 5' iodothyronine deiodinase (5' DI) catalyzes the deiodination of T4 to the biologically active hormone T3 and accounts for a significant fraction of its production.
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ TPOup-regulates quantity img/direct-activation.png chemical modification 3,3',5'-triiodothyronine 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267039 Homo sapiens
pmid sentence
The synthesis of T3 and T4 is achieved through the transfer of an iodophenoxyl group from a MIT or DIT residue called a “donor” onto a DIT residue called an “acceptor”. TPO seems to be primarily responsible for catalyzing the oxidations of iodotyrosines.
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ 3,3',5'-triiodothyronineup-regulates activity img/direct-activation.png chemical activation DIO 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-270246 Homo sapiens COS Cell
pmid sentence
Human type III iodothyronine deiodinase (D3) catalyzes the conversion of T(4) to rT(3) and of T(3) to 3, 3'-diiodothyronine (T2) by inner-ring deiodination. Like types I and II iodothyronine deiodinases, D3 protein contains selenocysteine (SeC) in the highly conserved core catalytic center at amino acid position 144.
Publications: 1 Organism: Homo Sapiens
+ 3-iodo-L-tyrosineup-regulates quantity img/direct-activation.png precursor of 3,3',5'-triiodothyronine 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268128 Homo sapiens
pmid sentence
The synthesis of T3 and T4 is achieved through the transfer of an iodophenoxyl group from a MIT or DIT residue called a “donor” onto a DIT residue called an “acceptor”. TPO seems to be primarily responsible for catalyzing the oxidations of iodotyrosines.
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ L-thyroxineup-regulates quantity img/direct-activation.png precursor of 3,3',5'-triiodothyronine 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266940 Homo sapiens
pmid sentence
Human type III iodothyronine deiodinase (D3) catalyzes the conversion of T(4) to rT(3) and of T(3) to 3, 3'-diiodothyronine (T2) by inner-ring deiodination. Like types I and II iodothyronine deiodinases, D3 protein contains selenocysteine (SeC) in the highly conserved core catalytic center at amino acid position 144.
Identifier Residue Sequence Organism Cell Line
SIGNOR-266943 Homo sapiens
pmid sentence
The type I 5' iodothyronine deiodinase (5' DI) catalyzes the deiodination of T4 to the biologically active hormone T3 and accounts for a significant fraction of its production.
Identifier Residue Sequence Organism Cell Line
SIGNOR-267042 Homo sapiens
pmid sentence
Thyroid hormone (TH) deiodinases play a pivotal role in the functional diversification of TH signaling. They are involved in development, growth, and metabolic processes, and act in a cell-specific manner in the fine regulation of TH homeostasis. TH deiodinases catalyze activation and inactivation of THs through the removal of one iodine atom in the outer or inner ring of the TH molecule. 
Identifier Residue Sequence Organism Cell Line
SIGNOR-266948 Homo sapiens
pmid sentence
Type II iodothyronine deiodinase (DII), which catalyzes deiodination of thyroxine (T4) exclusively on the outer ring (5’-position) to yield T3
Identifier Residue Sequence Organism Cell Line
SIGNOR-268127 Homo sapiens
pmid sentence
Type II iodothyronine deiodinase (DII), which catalyzes deiodination of thyroxine (T4) exclusively on the outer ring (5’-position) to yield T3
Publications: 5 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ 3,3',5'-triiodothyronineup-regulates img/indirect-activation.png Fatty_Acid_Biosynthesis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-267488 Homo sapiens
pmid sentence
TH stimulates both lipolysis and lipogenesis, although the direct action is lipolysis with lipogenesis thought to be stimulated to restore fat stores. Fatty acids produced from TH-induced lipolysis are the substrate for the increase in thermogenesis.
Publications: 1 Organism: Homo Sapiens
Tissue: Liver
Pathways:Thyroid Hormone Metabolism
+ 3,3',5'-triiodothyronineup-regulates activity img/direct-activation.png binding, chemical activation THRA 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267255 Homo sapiens
pmid sentence
T3 binds its receptor (TR) in the nucleus. TRs are ligand-dependent transcription factors belonging to the type II group of NHRs. TRs are encoded by two genes, Thra and Thrb.
Identifier Residue Sequence Organism Cell Line
SIGNOR-258385 Rattus norvegicus Liver
pmid sentence
We determined the affinity for T3 and analog binding characteristics of the translational products of c-erbA a- and /3-probes together with hepatic nuclear extracts.
Publications: 2 Organism: Homo Sapiens, Rattus Norvegicus
Tissue: Hypophysis
Pathways:Thyroid Hormone Metabolism
+ 3,5-diiodo-L-tyrosineup-regulates quantity img/direct-activation.png precursor of 3,3',5'-triiodothyronine 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268121 Homo sapiens
pmid sentence
The synthesis of T3 and T4 is achieved through the transfer of an iodophenoxyl group from a MIT or DIT residue called a “donor” onto a DIT residue called an “acceptor”. TPO seems to be primarily responsible for catalyzing the oxidations of iodotyrosines.
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ 3,3',5'-triiodothyronineup-regulates img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-267619 Homo sapiens
pmid sentence
Skeletal muscle has been recognized as a key TH target for contractile function, regeneration, and transport as well as for metabolism and glucose disposal (237, 238). TH stimulation favors transition to fast-twitch fibers and transition to a faster myosin heavy chain (MHC) form.
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ DIO3up-regulates quantity img/direct-activation.png chemical modification 3,3',5'-triiodothyronine 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266942 Homo sapiens
pmid sentence
Human type III iodothyronine deiodinase (D3) catalyzes the conversion of T(4) to rT(3) and of T(3) to 3, 3'-diiodothyronine (T2) by inner-ring deiodination. Like types I and II iodothyronine deiodinases, D3 protein contains selenocysteine (SeC) in the highly conserved core catalytic center at amino acid position 144.
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ SLC16A2down-regulates quantity img/direct_inhibition.png relocalization 3,3',5'-triiodothyronine 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267139 Homo sapiens
pmid sentence
T4 and T3 are released from the thyroid cell through transporters present at the basolateral plasma membrane of thyrocytes (Fig. 1). The most important transporter known to be responsible for thyroid hormone transport is the SLC16A2 monocarboxylate transporter 8 (MCT8), which can promote both uptake and efflux of TH and is involved in the release of TH from the thyroid gland.
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ 3,3',5'-triiodothyronineup-regulates activity img/direct-activation.png binding THR 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267276 Homo sapiens
pmid sentence
T3 binds its receptor (TR) in the nucleus. TRs are ligand-dependent transcription factors belonging to the type II group of NHRs. TRs are encoded by two genes, Thra and Thrb.
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ 3,3',5'-triiodothyronineup-regulates img/indirect-activation.png Gluconeogenesis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-267490 Homo sapiens
pmid sentence
It has been previously established that T3 stimulates gluconeogenesis, especially in the hyperthyroid state, and that hypothyroidism is associated with reduced gluconeogenesis.
Publications: 1 Organism: Homo Sapiens
Tissue: Liver
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