| + |
DIO | up-regulates quantity 
chemical modification
|
3,3',5'-triiodothyronine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267809 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20978344 |
The deiodinase family of enzymes controls the tissue-specific activation and inactivation of the prohormone thyroxine (T4) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267044 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34674502 |
Thyroid hormone (TH) deiodinases play a pivotal role in the functional diversification of TH signaling. They are involved in development, growth, and metabolic processes, and act in a cell-specific manner in the fine regulation of TH homeostasis. TH deiodinases catalyze activation and inactivation of THs through the removal of one iodine atom in the outer or inner ring of the TH molecule.  |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
DIO | up-regulates quantity by expression 
transcriptional regulation
|
MYOD1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270306 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20978344 |
The active thyroid hormone 3,5,3' triiodothyronine (T3) is a major regulator of skeletal muscle function. The deiodinase family of enzymes controls the tissue-specific activation and inactivation of the prohormone thyroxine (T4). Here we show that type 2 deiodinase (D2) is essential for normal mouse myogenesis and muscle regeneration. Indeed, D2-mediated increases in T3 were essential for the enhanced transcription of myogenic differentiation 1 (MyoD) and for execution of the myogenic program. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNF | down-regulates quantity by repression 
transcriptional regulation
|
DIO |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267811 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 9397972 |
From the results in Figs. 1-3, it is clear that several cytokines reduce the expression of 5’-DI mRNA and enzymatic activity in FRTL-5 cells grown in TSH-containing medium. These include TNF-a, IL-lb and INF-g but not TGF-b. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270239 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 9397972 |
From the results in Figs. 1-3, it is clear that several cytokines reduce the expression of 5’-DI mRNA and enzymatic activity in FRTL-5 cells. These include TNF-a, IL-lb and INF-y. |
|
| Publications: |
2 |
Organism: |
Rattus Norvegicus |
| + |
IFNG | down-regulates quantity by repression
transcriptional regulation
|
DIO |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270238 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 9397972 |
From the results in Figs. 1-3, it is clear that several cytokines reduce the expression of 5’-DI mRNA and enzymatic activity in FRTL-5 cells. These include TNF-a, IL-lb and INF-y. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267810 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 9397972 |
From the results in Figs. 1-3, it is clear that several cytokines reduce the expression of 5’-DI mRNA and enzymatic activity in FRTL-5 cells grown in TSH-containing medium. These include TNF-a, IL-lb and INF-g but not TGF-b. |
|
| Publications: |
2 |
Organism: |
Rattus Norvegicus |
| + |
IL1B | down-regulates quantity by repression
transcriptional regulation
|
DIO |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267812 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 9397972 |
From the results in Figs. 1-3, it is clear that several cytokines reduce the expression of 5’-DI mRNA and enzymatic activity in FRTL-5 cells grown in TSH-containing medium. These include TNF-a, IL-lb and INF-g but not TGF-b. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270241 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 9397972 |
From the results in Figs. 1-3, it is clear that several cytokines reduce the expression of 5’-DI mRNA and enzymatic activity in FRTL-5 cells. These include TNF-a, IL-lb and INF-y. |
|
| Publications: |
2 |
Organism: |
Rattus Norvegicus |
| + |
UBE2J1 | down-regulates quantity by destabilization 
ubiquitination
|
DIO |
0.387 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270242 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29892818 |
ER residency places D2 physically close to an array of proteins that interact and modify the D2 molecule via ubiquitination and targeting to the proteasomal system, explaining its relatively short half-life. Both ubiquitin conjugases UBC6 and or UBC7 interact with D2 and support D2 ubiquitination. Two Lys residues in D2 are involved in this process, K237 and K244. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Thyroid Gland |
| + |
DIO | down-regulates quantity
chemical modification
|
L-thyroxine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267043 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34674502 |
Thyroid hormone (TH) deiodinases play a pivotal role in the functional diversification of TH signaling. They are involved in development, growth, and metabolic processes, and act in a cell-specific manner in the fine regulation of TH homeostasis. TH deiodinases catalyze activation and inactivation of THs through the removal of one iodine atom in the outer or inner ring of the TH molecule.  |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DIO | up-regulates quantity
chemical modification
|
iodide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267045 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34674502 |
Thyroid hormone (TH) deiodinases play a pivotal role in the functional diversification of TH signaling. They are involved in development, growth, and metabolic processes, and act in a cell-specific manner in the fine regulation of TH homeostasis. TH deiodinases catalyze activation and inactivation of THs through the removal of one iodine atom in the outer or inner ring of the TH molecule.  |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
6-propyl-2-thiouracil | down-regulates activity
chemical inhibition
|
DIO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270240 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27347897 |
The activity of D1 but not D2 or D3 is inhibited by 6n-propylthiouracil (PTU). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Thyroid Gland |
| + |
DIO | up-regulates quantity
small molecule catalysis
|
3,3'-diiodothyronine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270307 |
|
|
Homo sapiens |
COS Cell |
| pmid |
sentence |
| 12746313 |
Human type III iodothyronine deiodinase (D3) catalyzes the conversion of T(4) to rT(3) and of T(3) to 3, 3'-diiodothyronine (T2) by inner-ring deiodination. Like types I and II iodothyronine deiodinases, D3 protein contains selenocysteine (SeC) in the highly conserved core catalytic center at amino acid position 144. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
3',5'-cyclic AMP | up-regulates quantity by expression
|
DIO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270243 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29892818 |
Dio2 is a cAMP responsive gene. Thus, any signaling pathway or molecule that increases cAMP concentration will stimulate D2 activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
3,3',5'-triiodothyronine | up-regulates activity
chemical activation
|
DIO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270246 |
|
|
Homo sapiens |
COS Cell |
| pmid |
sentence |
| 12746313 |
Human type III iodothyronine deiodinase (D3) catalyzes the conversion of T(4) to rT(3) and of T(3) to 3, 3'-diiodothyronine (T2) by inner-ring deiodination. Like types I and II iodothyronine deiodinases, D3 protein contains selenocysteine (SeC) in the highly conserved core catalytic center at amino acid position 144. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UBE2G2 | down-regulates quantity by destabilization
ubiquitination
|
DIO |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270244 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29892818 |
ER residency places D2 physically close to an array of proteins that interact and modify the D2 molecule via ubiquitination and targeting to the proteasomal system, explaining its relatively short half-life. Both ubiquitin conjugases UBC6 and or UBC7 interact with D2 and support D2 ubiquitination. Two Lys residues in D2 are involved in this process, K237 and K244. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Thyroid Gland |
| + |
FOXO3 | up-regulates quantity by expression
transcriptional regulation
|
DIO |
0.35 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270245 |
|
|
|
|
| pmid |
sentence |
| 20978344 |
Forkhead box O3 (FoxO3) was identified as a key molecule inducing D2 expression and thereby increasing intracellular T3 production. Accordingly, FoxO3-depleted primary myoblasts also had a differentiation deficit that could be rescued by high levels of T3. |
|
| Publications: |
1 |
| + |
DIO | up-regulates quantity
small molecule catalysis
|
3,3',5'-triiodo-L-thyronine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270305 |
|
|
|
|
| pmid |
sentence |
| 20978344 |
The deiodinase family of enzymes controls the tissue-specific activation and inactivation of the prohormone thyroxine (T4) |
|
| Publications: |
1 |
3.0
DIO