| + |
APAF1 | up-regulates activity 
binding
|
CASP9 |
0.953 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135381 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15829969 |
During apoptosis, Apaf-1 binds to cytochrome c and in the presence of ATP/dATP forms an apoptosome, leading to the recruitment and activation of the initiator caspase, caspase-9 . |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53576 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9390557 |
Caspase-9 and Apaf-1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome c and dATP, an event that leads to caspase-9 activation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS |
| + |
HSPA1A | down-regulates 
binding
|
APAF1 |
0.447 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80451 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10934467 |
Here we show that the documented anti-apoptotic effect of the principal heat-shock protein, hsp70, is mediated through its direct association with the caspase-recruitment domain (card) of apaf-1 and through apoptosome formation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CYCS | up-regulates activity
binding
|
APAF1 |
0.787 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-149574 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16977332 |
Apaf-1 exists in an inactive conformation in cells and is activated through binding to cytochrome c and dATP. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-137295 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15907471 |
Cytochrome c (Cyt c) is then released from the intermembrane space of the mitochondrion into the cytosol, where it binds to apoptotic protease-activating factor 1 (Apaf-1) in the presence of ATP/dATP to form the apoptosome. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135384 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15829969 |
During apoptosis, Apaf-1 binds to cytochrome c and in the presence of ATP/dATP forms an apoptosome, leading to the recruitment and activation of the initiator caspase, caspase-9. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-50585 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9267021 |
Once released from mitochondria, cytochrome c binds to Apaf-1, which may trigger the activation of caspase-3 in the presence of dATP. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS |
| + |
HSP90AB1 | down-regulates
binding
|
APAF1 |
0.402 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-81043 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10944114 |
The present studies demonstrate that heat shock protein 90 (hsp90) forms a cytosolic complex with apaf-1 and thereby inhibits the formation of the active complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APIP | down-regulates
binding
|
APAF1 |
0.547 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-126797 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15262985 |
Taken together, these results suggest that apip functions to inhibit muscle ischemic damage by binding to apaf-1 in the apaf-1/caspase-9 apoptosis pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BCL2L1 | down-regulates activity
binding
|
APAF1 |
0.837 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-56399 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9539746 |
These experiments demonstrate that bcl-xl associates with caspase-9 and apaf-1, and show that bcl-xl inhibits the maturation of caspase-9 mediated by apaf-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS |
| + |
APAF1 | form complex 
binding
|
Apoptosome |
0.87 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256431 |
|
|
in vitro |
|
| pmid |
sentence |
| 10206961 |
APAF-1 binds and hydrolyzes ATP or dATP to ADP or dADP, respectively. The hydrolysis of ATP/dATP and the binding of cytochrome c promote APAF-1 oligomerization, forming a large multimeric APAF-1.cytochrome c complex. Such a complex can be isolated using gel filtration chromatography and is by itself sufficient to recruit and activate procaspase-9. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Alzheimer |
| + |
APAF1 | up-regulates
binding
|
CASP9 |
0.953 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53579 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9390557 |
During apoptosis, apaf-1 binds to cytochrome c and in the presence of atp/datp forms an apoptosome, leading to the recruitment and activation of the initiator caspase, caspase-9 .in particular, caspase-9 is recruited and activated by apaf-1 .casp9 and apaf-1 bind to each other via their respective nh2-terminal ced-3 homologous domains in the presence of cycs and datp, an event that leads to casp9 activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS |
3.0
APAF1
- 
- 