4.0
Summary
| Name |  TLR3View Modifications |
| Full Name | Toll-like receptor 3 |
| Synonyms | TLR3_HUMAN |
| Primary ID | O15455 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SRC | up-regulates activity 
phosphorylation
|
TLR3 | 0.527 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EGFR | up-regulates activity
phosphorylation
|
TLR3 | 0.426 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | STAT1 | up-regulates quantity by expression 
transcriptional regulation
|
TLR3 | 0.447 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | E2F1 | down-regulates quantity by repression 
transcriptional regulation
|
TLR3 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |