Relation Results

Summary

Name TLR3
Full Name Toll-like receptor 3
Synonyms TLR3_HUMAN
Primary ID O15455
Links - -
Type protein
Relations 2
Function Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecu ...
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Type: Score: Layout: SPV 
0.4490.2STAT1TLR3E2F1

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Relations
Regulator
Mechanism
target
score ℹ
+ STAT1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TLR3 0.449
Identifier Residue Sequence Organism Cell Line
SIGNOR-255230 Homo sapiens
pmid sentence
The activation of STAT1 by IFNs not only induces chemokine production, but also results in the expression of IRF-7 and TLR3, thus amplifying the dsRNA-provoked reaction in a positive-feedback manner during viral infection.
Publications: 1 Organism: Homo Sapiens
+ E2F1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TLR3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254136 Mus musculus
pmid sentence
Together, these data indicated that E2F1 suppresses TLR3 transcription, but during immune stimulation, Rb is upregulated to block the inhibitory effect of E2F1 on TLR3, highlighting a role of Rb-E2F1 axis in the innate immune response in epithelial cells.
Publications: 1 Organism: Mus Musculus
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